Prognostic and pathological impact of tumor budding in gastric cancer: A systematic review and meta-analysis

Table 1 Main characteristics of the included studies

Author	Year	Country	Cases	Cancer	Stage	Staining	Cut off	Microscopic magnification	Survival analysis	Newcastle-Ottawa score
Gabbert et al[14]	1992	Germany	445	GC	I-IV	HE	5 buds	NA	OS	7
Brown et al[17]	2010	UK	356	EGJA	I-IV	HE	5 buds	NA	OS	7
Tanaka et al[18]	2014	Japan	320	GC	I-IV	HE	Median	× 400	OS	8
Gulluoglu et al[19]	2015	Turkey	126	GC	I	HE	5 buds	× 400	NA	4
Che et al[20]	2017	China	296	GC	I-IV	HE	5 buds	× 400	OS	8
Olsen et al[21]	2017	USA	52	GC	I-IV	HE	Median	× 200	PFS	6
Kemi et al[15]	2019	Finland	583	GC	I-IV	HE	10 buds	× 400	OS	8

UK: United Kingdom; USA: United States; HE: Hematoxylin eosin stain; NA: Not applied; OS: Overall survival; PFS: Progression free survival