Editorial
Copyright ©2009 Baishideng.
World J Gastrointest Oncol. Oct 15, 2009; 1(1): 12-20
Published online Oct 15, 2009. doi: 10.4251/wjgo.v1.i1.12
Table 1 Amsterdam I and II criteria and Bethesda (revised) guidelines
TermCriteria
Amsterdam I[65] (All criteria must be met)At least three 1st degree relatives with CRC
At least two successive generations affected
At least one family member diagnosed below age 50
FAP excluded
Amsterdam II[65] (All criteria must be met)As for AmsterdamI except that CRC may be substituted by any of: CRC, cancer of the endometrium, small bowel, ureter, or renal pelvis
Bethesda (revised)[66]Test for MSI if: (Any criterion met)
1CRC diagnosed below age 50
2Presence of multiple CRC or HNPCC-related cancers1 (synchronous or metachronous)
3CRC with MSI-H-related histology2 diagnosed below age 60
4CRC or HNPCC-related cancer in at least one 1st degree relative, diagnosed below age 50
5CRC or HNPCC-related cancer in at least two 1st or 2nd degree relatives, regardless of age
1Includes cancer of endometrium, small bowel, pelviureter, biliary tract, stomach, ovary, pancreas, and brain (mainly glioblastoma multiforme);
2Tumor infiltrating lymphocytes, Crohn-like reaction, mucin/signet ring cell differentiation, medullary growth pattern.