Copyright ©The Author(s) 2016.
World J Gastrointest Oncol. Apr 15, 2016; 8(4): 358-365
Published online Apr 15, 2016. doi: 10.4251/wjgo.v8.i4.358
Table 1 Summary of chromodomain-helicase-DNA binding protein 5, 7 and mixed lineage kinase domain-like protein biomarkers in pancreatic adenocarcinoma
BiomarkerPathway affectedBiomarker type for pancreatic cancer from literature and studies? (prognostic, predictive, diagnostic)Mechanism of actionOther cancersComments
CHD5[33]DDRPrognosticTumor suppressor gene. Binds to histone 3Epigenetically silenced in neuroblastoma[37], colorectal cancer[38], breast cancer[39], cervical cancer[39], hepatocarcinoma[39], gastric cancer[40] and lung cancer[41]. Mutations found in head and neck squamous cell carcinoma[42], prostate cancer[43], ovarian cancer[44], ovarian clear cell carcinoma[45], cutaneous melanoma[46], hepatocellular carcinoma[47], neuroblastoma[48], breast and colorectal cancer[49]Low expression correlates with worse clinical outcomes
CHD7[66]DDRPrognosticInteracts with SOX2 to regulate gene expression-Decreased expression is associated with improved clinical outcomes
MLKL[74]NecroptosisPrognosticForms necrosis- inducing complex called a “necrosome” along with RIPK1 and RIPK3Ovarian[75]Low expression is associated with worse clinical outcomes