Copyright ©The Author(s) 2016.
World J Gastrointest Oncol. Jan 15, 2016; 8(1): 99-104
Published online Jan 15, 2016. doi: 10.4251/wjgo.v8.i1.99
Table 1 Ongoing clinical trials in Immunotherapy in colorectal cancer
Drug IdentifierSponsorRemarks
AMP-224PD-1 inhibitor1NCT02298946NCICombination with stereotactic body radiation therapy
MPDL3280AEngineered anti-PDL1 antibody1NCT01375842GenentechAdministered as single agent
Varlilumab and nivolumabMonoclonal antibodies that binds to CD27 and PD-11/2NCT02335918Celldex therapeutics/bristol-myers squibbPhase II to determine objective response rate
MPDL3280A and bevacizumabEngineered anti-PDL1 antibody1bNCT01633970GenentechAssess the safety, pharmacology and preliminary efficacy of the combination
AvelumabAntibody targeting PDL-11NCT01772004EMD seronoOpen-label, dose-escalation trial
MEDI4736Anti PDL-12NCT02227667Memorial sloan Kettering cancer centerStudy to evaluate the efficacy of MEDI4736