Anti program death-1/anti program death-ligand 1 in digestive cancers

Figure 1 From a resting T cell to an activated or an anergic T cell. To be activated a T cell lymphocyte needs recognition of an antigen coupled with major histocompatibility complex by its specific TCR, adequate cytokines and activation of co-stimulatory molecules such as CD28. An inhibitory signal can instead be transmitted by co-inhibitory molecules (PD-1, CTLA-4, Lag 3, Tim 3…) and lead to T cell anergy. TCR: T cell receptor; CD28: Cluster of differenciation 28; HLA: Human leucocyte antigen; CD80/86: Cluster of differenciation CD80/86; PD-1: Program death-1; PD-L1: Program death-ligand 1; CTLA-4: Cytotoxic T-lymphocyte-associated protein 4.