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Copyright ©The Author(s) 2015.
World J Gastrointest Oncol. Nov 15, 2015; 7(11): 285-291
Published online Nov 15, 2015. doi: 10.4251/wjgo.v7.i11.285
Table 1 Phase I studies on intraperitoneal chemotherapy using taxanes for the treatment of gastric cancer with peritoneal carcinomatosis
Ref.nIntraperitoneally administered taxanesInitial dose(mg/m2)MTD(mg/m2)RD(mg/m2)DLT
Kodera et al[42]4PTX60---
Fushida et al[26]24DOC256045Abdominal pain and
Ishigami et al[45]9PTX203020Febrile neutropenia and diarrhea
Fujiwara et al[43]12DOC40-60-
Kurita et al[44]18PTX409080Leukocytopenia
Fushida et al[16]12DOC355045Febrile neutropenia and diarrhea