Analysis of the potential biological value of pyruvate dehydrogenase E1 subunit β in human cancer

Figure 11  Enrichment analysis of pyruvate dehydrogenase E1 subunit β-associated genes in pan-cancer. A: Interaction network of pyruvate dehydrogenase E1 subunit β (PDHB)-associated biomarkers derived from the BioGRID database; B: GEPIA2.0 showed that PDHB expression was positively correlated with actin related protein 8 (ACTR8), potassium channel tetramerization domain containing 6 (KCTD6), mutl homolog 1 (MLH1), proteasome 26s subunit, non-ATPase 6 (PSMD6), ribonuclease P/MRP subunit p14 (RPP14), and ubiquitin specific peptidase 19 (USP19) genes; C: Heat map showing PDHB expression positively correlated with 6 genes (ACTR8, KCTD6, MLH1, PSMD6, RPP14, USP19); D: Enrichment analysis of PDHB-related genes. PDHB: Pyruvate dehydrogenase E1 subunit β. ACC: Adrenocortical carcinoma; BLCA: Bladder urothelial carcinoma; BRCA: Breast invasive carcinoma; CESC: Cervical squamous cell carcinoma and Endocervical adenocarcinoma; CHOL: Cholangiocarcinoma; COAD: Colon adenocarcinoma; DLBC: Lymphoid neoplasm diffuse large B-cell lymphoma; ESCA: Esophageal carcinoma; GBM: Glioblastoma multiforme; HNSC: Head and Neck squamous cell carcinoma; KICH: Kidney chromophobe; KIRC: Kidney renal clear cell carcinoma; KIRP: Kidney renal papillary cell carcinoma; LAML: Acute myeloid leukemia; LGG: Brain lower grade glioma; LIHC: Liver hepatocellular carcinoma; LUAD: Lung adenocarcinoma; LUSC: Lung squamous cell carcinoma; MESO: Mesothelioma; OV: Ovarian serous cystadenocarcinoma; PAAD: Pancreatic adenocarcinoma; PCPG: Pheochromocytoma and Paraganglioma; PRAD: Prostate adenocarcinoma; READ: Rectum adenocarcinoma; SKCM: Skin cutaneous melanoma; STAD: Stomach adenocarcinoma; TGCT: Testicular germ cell tumors; THCA: Thyroid carcinoma; THYM: Thymoma; UCEC: Uterine corpus endometrial carcinoma; UCS: Uterine carcinosarcoma; UVM: Uveal melanoma.