Adenosquamous carcinoma may have an inferior prognosis to signet ring cell carcinoma in patients with stages I and II gastric cancer

Table 4 Cox regression analysis of cancer-specific survival (n = 465)

Characteristic	Univariate Cox		Multivariate Cox
	HR (95%CI)	P value	HR (95%CI)	P value
Histological type
SRC	Reference		Reference
ASC	1.343 (1.029-1.752)	0.030	1.316 (1.004-1.726)	0.047
Age (yr)
≤ 60	Reference		NI
> 60	1.027 (0.819-1.288)	0.815
Gender
Male	Reference		NI
Female	0.952 (0.740-1.223)	0.698
Race
White	Reference		NI
Black	1.199 (0.870-1.652)	0.268
Others	0.883 (0.597-1.304)	0.531
Marital status
Not married	Reference		Reference
Married	0.768 (0.593-0.994)	0.045	0.709 (0.540-0.932)	0.014
Tumor size (mm)
≤ 50	Reference		Reference
> 50	1.994 (1.587-2.503)	<0.001	1.217 (0.947-1.564)	0.125
Stage
I	Reference		Reference
II	1.482 (0.993-2.212)	0.054	1.564 (1.021-2.394)	0.040
III	2.472 (1.714-3.564)	< 0.001	2.460 (1.601-3.780)	< 0.001
IV	5.179 (3.739-7.175)	< 0.001	2.884 (1.665-4.997)	< 0.001
Tumor depth
T1	Reference		Reference
T2	0.962(0.705-1.312)	0.805	1.296 (0.923-1.821)	0.135
T3	1.478(1.051-2.077)	0.025	1.482 (0.986-2.228)	0.058
T4	1.801 (1.243-2.609)	0.002	1.070 (0.699-1.638)	0.757
LN metastasis
N0	Reference		NI
N1	0.978(0.760-1.258)	0.863
N2	1.218 (0.901-1.647)	0.200
N3	1.642 (0.985-2.737)	0.057
Distant metastasis
No	Reference		Reference
Yes	4.303 (3.397-5.451)	< 0.001	1.278 (0.778-2.100)	0.333
Radiotherapy
No	Reference		Reference
Yes	0.484(0.383-0.612)	< 0.001	0.587 (0.444-0.776)	< 0.001
Surgery
No	Reference		Reference
Yes	0.244(0.192-0.311)	< 0.001	0.450 (0.319-0.635)	< 0.001

HR: Hazard ratio; NI: Not included; LN: Lymph node; SRC: Signet ring cell carcinoma; ASC: Adenosquamous carcinoma; TNM: Tumor-node-metastasis.