Hepatic resection vs percutaneous radiofrequency ablation of hepatocellular carcinoma abutting right diaphragm

Table 3 Univariate and multivariate analysis of prognostic factors for disease-free survival

Variable	Univariate analysis		Multivariate analysis
	HR	P value	HR	P value
Group (RF ablation)	0.272 (0.174, 0.427)	< 0.001	0.352 (0.205, 0.605)	< 0.001
Age	1.036 (1.012, 1.060)	0.003	1.015 (0.987, 1.043)	0.306
Sex (female)	1.096 (0.650, 1.847)	0.732
Etiology (hepatitis B virus) 1		0.726
Hepatitis C virus	1.507 (0.789, 2.878)	0.31
NBNC	1.121 (0.483, 2.601)	1
Liver cirrhosis (absence)	1.526 (0.916, 2.544)	0.105
Tumor size	0.976 (0.658, 1.448)	0.904
α-fetoprotein	1.000 (0.999, 1.000)	0.391
Platelet count	0.991 (0.987, 0.995)	< 0.001	0.998 (0.993, 1.004)	0.542
Alanine aminotransferase	1.008 (1.000, 1.017)	0.045	1.011 (1.003, 1.020)	0.006
Total bilirubin	0.995 (0.540, 1.833)	0.988
Albumin	0.281 (0.168, 0.470)	< 0.001	0.481 (0.269, 0.860)	0.014
Prothrombin time (INR)	147.887 (13.992, 1563.115)	< 0.001	4.212 (0.195, 90.886)	0.359

The Cox proportional hazards model was used for univariate and multivariate analysis. The reference category for each categorical variable is in the square brackets in first column. ¹Bonferroni correction was used owing to multiple comparisons. Numbers in parentheses represent the 95%CI. HR: Hazard ratio; RF: Radiofrequency; NBNC: Non-B non-C; INR: International normalized ratio.