Modulators affecting the immune dialogue between human immune and colon cancer cells

Figure 1 Interrelationship between peripheral blood mononuclear cells and human colon cancer cells. A: Unstimulated peripheral blood mononuclear cells (PBMC) do not release significant amount of inflammatory cytokines. B: Following direct contact with cancer cells PBMC are stimulated for pro-inflammatory (red dots) and anti-inflammatory (yellow dots) cytokine production.

Figure 2 Schematic presentation of the way immune modulators modify the cross-talk between peripheral blood mononuclear cells and cancer cells. Following alteration of the immune dialogue between these two cell types, the modulators inhibit cancer cell-stimulated peripheral blood mononuclear cells (PBMC) to generate pro-inflammatory cytokine (red dots), acting as cancer promoters.