Aberrant crypt focus and fragile histidine triad protein in sporadic colorectal carcinoma

Figure 1 Medium power photomicrograph. A: Medium power photomicrograph of colonic mucosa taken from the areas of granular mucosa showing hyperplastic aberrant crypt focus (ACF) [hematoxylin eosin (HE), × 300]; B: Medium power photomicrograph of normal colonic mucosa showing diffuse and strong expression for Fhit protein [peroxidase anti-peroxidase (PAP), × 300]; C: Medium power photomicrograph of colonic mucosa taken from the granular mucosa closed to the tumor showing dysplastic ACF (HE, × 250); D: Medium power photomicrograph of hyperplastic ACF showing diffuse but weaker cytoplasmic Fhit protein expression (PAP, × 300); E: Medium power photomicrograph of dysplastic ACF showing weak cytoplasmic Fhit protein expression (PAP, × 250); F: Medium power photomicrograph of a colonic adenocarcinoma showing a negative staining for Fhit protein (PAP, × 250).