Dietary eicosapentaenoic and docosahexaenoic acids decrease prostanoids in the ileum of rats treated with irinotecan and 5-fluorouracil

doi:10.4251/wjgo.120472

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World Journal of Gastrointestinal Oncology

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1948-5204

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 120472
Published online Sep 15, 2026. doi: 10.4251/wjgo.120472

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Figure 1 Pathophysiology of irinotecan and 5-fluorouracil on ileal membrane phospholipid when enriched with eicosapentaenoic acid and docosahexaenoic acid. CPT-11: Irinotecan; 5-FU: 5-fluorouracil; AA: Arachidonic acid; PLA₂: Phospholipase A₂; LOX: Lipoxygenase; COX: Cyclooxygenase; HETE: Hydroxyeicosatetraenoic acid; LTB₄: Leukotriene-B₄; PG: Prostaglandin; TX: Thromboxane; DHA: Docosahexaenoic acid; EPA: Eicosapentaenoic acid; NE: Non-enzymatic; CYP: Cytochrome P450; HDoHE: Hydroxy-docosahexaenoic acid.

Citation: Parsons SR, Rivas-Serna IM, Clandinin MT, Mazurak VC. Dietary eicosapentaenoic and docosahexaenoic acids decrease prostanoids in the ileum of rats treated with irinotecan and 5-fluorouracil. World J Gastrointest Oncol 2026; 18(9): 120472
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/120472.htm
DOI: https://dx.doi.org/10.4251/wjgo.120472

Parsons SR, Rivas-Serna IM, Clandinin MT, Mazurak VC. Dietary eicosapentaenoic and docosahexaenoic acids decrease prostanoids in the ileum of rats treated with irinotecan and 5-fluorouracil. World J Gastrointest Oncol 2026; 18(9): 120472 [DOI: 10.4251/wjgo.120472]

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