Association between lymphopenia and the survival of patients with colorectal cancer: A meta-analysis

Figure 1 Flowchart of the database search and study inclusion. Consider, if feasible to do so, reporting the number of records identified from each database or register searched (rather than the total number across all databases/registers). If automation tools were used, indicate how many records were excluded by a human and how many were excluded by automation tools.

Figure 2 Forest plots for the meta-analysis of the association between lymphopenia and progression-free survival in patients with colorectal cancer. A: Overall meta-analysis; B: Subgroup analysis according to study country; C: Subgroup analysis according to the mean patient age.

Figure 3 Forest plots for the subgroup analyses of the association between lymphopenia and progression-free survival in patients with colorectal cancer. A: Subgroup analysis according to the timing of lymphopenia evaluation; B: Subgroup analysis according to the absolute lymphocyte count cutoff for defining lymphopenia; C: Subgroup analysis according to the follow-up duration.

Figure 4 Forest plots for the meta-analysis of the association between lymphopenia and overall survival in patients with colorectal cancer. A: Overall meta-analysis; B: Subgroup analysis according to the study country; C: Subgroup analysis according to the mean patient age.

Figure 5 Forest plots for the subgroup analyses of the association between lymphopenia and overall survival in patients with colorectal cancer. A: Subgroup analysis according to the timing of lymphopenia evaluation; B: Subgroup analysis according to the absolute lymphocyte count cutoff for defining lymphopenia; C: Subgroup analysis according to the follow-up duration.

Figure 6 Funnel plots for estimating the potential publication biases underlying the meta-analyses of the association between lymphopenia and survival outcomes of patients with colorectal cancer. A: Funnel plots for the meta-analysis of the association between lymphopenia and progression-free survival; B: Funnel plots for the meta-analysis of the association between lymphopenia and overall survival.