Multidimensional integration: A novel breakthrough in prognostic prediction for immunochemotherapy in human epidermal growth factor receptor-2-negative advanced gastric cancer

doi:10.4251/wjgo.118614

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Sep 15, 2026; 18(9): 118614
Published online Sep 15, 2026. doi: 10.4251/wjgo.118614

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Figure 1 Multidimensional framework for prognostic prediction in human epidermal growth factor receptor-2-negative advanced gastric cancer undergoing immunochemotherapy. PD-L1: Programmed cell death ligand 1; MSI: Microsatellite instability; MMR: Mismatch repair; EBV: Epstein-Barr virus; ctDNA: Circulating tumor DNA; TNM: Tumor-node-metastasis; ECOG: Eastern Cooperative Oncology Group; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio; LMR: Lymphocyte-to-monocyte ratio; PNI: Prognostic nutritional index; CALLY: C-reactive protein-albumin-lymphocyte; CRP: C-reactive protein; PD-1: Programmed cell death protein 1; AI: Artificial intelligence.

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Figure 2 Current challenges and future directions of prognostic modeling in immunochemotherapy for advanced gastric cancer. PD-L1: Programmed cell death ligand 1; IHC: Immunohistochemistry; AI: Artificial intelligence; ctDNA: Circulating tumor DNA; ML: Machine learning.

Citation: Li MF, Du SN, Bao PT, Li YG. Multidimensional integration: A novel breakthrough in prognostic prediction for immunochemotherapy in human epidermal growth factor receptor-2-negative advanced gastric cancer. World J Gastrointest Oncol 2026; 18(9): 118614
URL: https://www.wjgnet.com/1948-5204/full/v18/i9/118614.htm
DOI: https://dx.doi.org/10.4251/wjgo.118614

Li MF, Du SN, Bao PT, Li YG. Multidimensional integration: A novel breakthrough in prognostic prediction for immunochemotherapy in human epidermal growth factor receptor-2-negative advanced gastric cancer. World J Gastrointest Oncol 2026; 18(9): 118614 [DOI: 10.4251/wjgo.118614]

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