Gallbladder cancer harboring ERBB2 mutation on the primary and metastatic site: A case report

Figure 1 Contrasted computed tomography images. A: Contrasted computed tomography scan before surgical biopsy. A hypoattenuating lesion with ill-defined margins was observed in the posterior lobe of the liver; B and C: Comparative contrasted computed tomography scan before (B), and after (C) 2 cycles of lapatinib and capecitabine treatment. Hepatic metastases were reduced in size and tumor emboli in inferior vena cava (arrow heads) was mostly disappeared with the therapy.

Figure 2 Tumor histology. A: Low-power microscopic view of the gallbladder cancer. The tumor cells form tubules of variable sizes. The tumor infiltrates deeply into the gallbladder wall; B: High-power microscopic view of the gallbladder cancer. Atypical columnar cells with enlarged nuclei grow in tubular structures. Stromal fibrosis and inflammation are also observed; C: Low-power microscopic view of the hepatic lesion. Adenocarcinoma with vaguely nodular contour involves the liver parenchyma; D: High-power microscopic view of the hepatic lesion. Glandular structure is predominant. The tumor cells have enlarged nuclei with coarse chromatin. Multiple mitoses are observed.