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Shi J, Ding F, Dai D, Song X, Wu X, Yan D, Han X, Tao G, Dai W. Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is suppressed by hsa-miR-200b-3p. Sci Rep 2024; 14:6568. [PMID: 38503887 PMCID: PMC10951337 DOI: 10.1038/s41598-024-57099-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/12/2023] [Accepted: 03/14/2024] [Indexed: 03/21/2024] Open
Abstract
While Phorbol-12-myristate-13-acetate-induced protein 1 (Noxa/PMAIP1) assumes a pivotal role in numerous tumors, its clinical implications and underlying mechanisms of gastric cancer (GC) are yet enigmatic. In this investigation, our primary objective was to scrutinize the clinical relevance and potential mechanisms of Noxa in gastric cancer. Immunohistochemical analysis was conducted on tissue microarrays comprising samples from a meticulously characterized cohort of 84 gastric cancer patients, accompanied by follow-up data, to assess the expression of Noxa. Additionally, Noxa expression levels in gastric cancer clinical samples and cell lines were measured through quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot analysis. The effect of Noxa expression on the prognosis of patients with gastric cancer was evaluated using Kaplan-Meier survival. Further insight into the role of Noxa in driving gastric cancer progression was gained through an array of experimental techniques, including cell viability assays (CCK8), plate cloning assays, transwell assays, scratch assays, and real-time cell analysis (RTCA). Potential upstream microRNAs (miRNAs) that might modulate Noxa were identified through rigorous bioinformatics analysis, substantiated by luciferase reporter assays and Western blot experiments. Additionally, we utilized RNA sequencing, qRT-PCR, and Western blot to identify proteins binding to Noxa and potential downstream target. Finally, we utilized BALB/c nude mice to explore the role of Noxa in vivo. Our investigation unveiled a marked downregulation of Noxa expression in gastric cancer and underscored its significance as a pivotal prognostic factor influencing overall survival (OS). Noxa overexpression exerted a substantial inhibitory effect on the proliferation, migration and invasion of GC cells. Bioinformatic analysis and dual luciferase reporter assays unveiled the capacity of hsa-miR-200b-3p to interact with the 3'-UTR of Noxa mRNA, thereby orchestrating a downregulation of Noxa expression in vitro, consequently promoting tumor progression in GC. Our transcriptome analysis, coupled with mechanistic validation, elucidated a role for Noxa in modulating the expression of ZNF519 in the Mitophagy-animal pathway. The depletion of ZNF519 effectively reversed the oncogenic attributes induced by Noxa. Upregulation of Noxa expression suppressed the tumorigenesis of GC in vivo. The current investigation sheds light on the pivotal role of the hsa-miR-200b-3p/Noxa/ZNF519 axis in elucidating the pathogenesis of gastric cancer, offering a promising avenue for targeted therapeutic interventions in the management of this challenging malignancy.
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Affiliation(s)
- Jin Shi
- Department of Gastrointestinal Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, People's Republic of China
| | - Fan Ding
- Department of Gastrointestinal Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, People's Republic of China
| | - Dezhu Dai
- Department of Gastrointestinal Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, People's Republic of China
| | - Xudong Song
- Department of Gastrointestinal Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, People's Republic of China
| | - Xu Wu
- Department of Vascular, Huaian Hospital Affiliated to Xuzhou Medical University, Huai'an, Jiangsu, 223300, People's Republic of China
| | - Dongsheng Yan
- Department of Gastrointestinal Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, People's Republic of China
| | - Xiao Han
- Department of Gastrointestinal Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, People's Republic of China
| | - Guoquan Tao
- Department of Gastrointestinal Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, People's Republic of China.
| | - Weijie Dai
- Department of Gastroenterology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, 223300, People's Republic of China.
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Yarahmadi A, Afkhami H. The role of microbiomes in gastrointestinal cancers: new insights. Front Oncol 2024; 13:1344328. [PMID: 38361500 PMCID: PMC10867565 DOI: 10.3389/fonc.2023.1344328] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/01/2023] [Accepted: 12/20/2023] [Indexed: 02/17/2024] Open
Abstract
Gastrointestinal (GI) cancers constitute more than 33% of new cancer cases worldwide and pose a considerable burden on public health. There exists a growing body of evidence that has systematically recorded an upward trajectory in GI malignancies within the last 5 to 10 years, thus presenting a formidable menace to the health of the human population. The perturbations in GI microbiota may have a noteworthy influence on the advancement of GI cancers; however, the precise mechanisms behind this association are still not comprehensively understood. Some bacteria have been observed to support cancer development, while others seem to provide a safeguard against it. Recent studies have indicated that alterations in the composition and abundance of microbiomes could be associated with the progression of various GI cancers, such as colorectal, gastric, hepatic, and esophageal cancers. Within this comprehensive analysis, we examine the significance of microbiomes, particularly those located in the intestines, in GI cancers. Furthermore, we explore the impact of microbiomes on various treatment modalities for GI cancer, including chemotherapy, immunotherapy, and radiotherapy. Additionally, we delve into the intricate mechanisms through which intestinal microbes influence the efficacy of GI cancer treatments.
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Affiliation(s)
- Aref Yarahmadi
- Department of Biology, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran
| | - Hamed Afkhami
- Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran
- Cellular and Molecular Research Center, Qom University of Medical Sciences, Qom, Iran
- Department of Medical Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran
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Ristau P, Oetting-Roß C, Büscher A. Coping in patients with pancreatic cancer: a scoping review and narrative synthesis. BMJ Support Palliat Care 2024; 13:e695-e706. [PMID: 34880064 DOI: 10.1136/bmjspcare-2021-003266] [Citation(s) in RCA: 3] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/04/2021] [Accepted: 11/10/2021] [Indexed: 11/04/2022]
Abstract
INTRODUCTION Pancreatic cancer is a malignant disease with one of the highest cancer-specific mortality rates. Coping with it probably differs from other malignant diseases. This scoping review was intended to explore and characterise academic literature related to the coping in patients with pancreatic cancer. METHODS Eight databases were searched for primary and secondary studies and reviews reporting on coping with pancreatic cancer (adenocarcinoma) in adults in English or German language, regardless of publication date or study design, which were then analysed and summarised by narrative synthesis. RESULTS Of 1472 publications identified, 9 articles and book contributions published from 1989 to 2020 in the USA, Europe and Australia met the inclusion criteria. The two main aspects covered were the confrontation with coping tasks, and the reciprocally associated coping with these challenges. In particular, the coping tasks revealed some pancreatic cancer-specific features, such as an increased incidence of depression and anxiety or certain digestive problems, whereas applying of coping strategies seems to be more like the coping behaviours known from the literature for other severe or cancer diseases. CONCLUSIONS Patients with pancreatic cancer experience various health issues and face various quality of life changes and coping tasks. Disease-specific contextual factors, usually consisting of late diagnosis at an advanced stage, rapid progression and often poor prognosis, as well as disease-specific challenges are major differences compared with other malignancies or serious illnesses. However, the coping strategies applied do not seem to differ in principle. Currently, no pancreatic cancer-specific coping model exists.
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Affiliation(s)
- Patrick Ristau
- Faculty of Health, School of Nursing Science, Witten/Herdecke University, Witten, Germany
| | | | - Andreas Büscher
- Faculty of Health, School of Nursing Science, Witten/Herdecke University, Witten, Germany
- Faculty of Business Management and Social Sciences, Osnabrück University of Applied Sciences, Osnabrück, Germany
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Lowe T, DeLuca J, Abenavoli L, Boccuto L. Familial pancreatic cancer: a case study and review of the psychosocial effects of diagnoses on families. Hered Cancer Clin Pract 2023; 21:17. [PMID: 37684686 PMCID: PMC10492294 DOI: 10.1186/s13053-023-00261-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/09/2023] [Accepted: 08/30/2023] [Indexed: 09/10/2023] Open
Abstract
BACKGROUND Familial pancreatic cancer touches families through a genetic susceptibility to developing this neoplasia. Genetic susceptibility is assessed via family history, genetic testing, or both. Individuals with two or more first-degree relatives or three or more relatives of any degree diagnosed with pancreatic cancer are considered at elevated risk. Following a diagnosis of familial pancreatic cancer, patients and families face uncertainty and anxiety about the future. Psychosocial effects of a pancreatic cancer diagnosis on families include fear, concerns about personal health, and how lifestyle may impact the risk of developing pancreatic cancer. CASE PRESENTATION A 66-year-old male was diagnosed with pancreatic ductal adenocarcinoma stage IIB, T3, N1, M0. A genetic referral was made due to a history of multiple cases of pancreatic cancer within the patient's family. Genetic testing revealed the patient had a pathogenic variant in the ATM gene that is associated with an increased risk for pancreatic cancer development. The patient's one adult child was offered testing due to the autosomal dominant pattern of inheritance for this variant. The adult child was found to have the same pathogenic variant. She expressed fear for her future and her child's future health and longevity. Discussing a case study allows us to capture the multi-faceted relationship between the disease, the affected individuals, and their families. Examining the psychosocial stresses and concerns when there is a pancreatic cancer diagnosis in the family is essential to provide holistic care to patients and families. CONCLUSIONS The psychosocial effects of FPC may be overwhelming for patients and families. Healthcare providers can offer education, support, and referrals to appropriate services to help families cope through stages of evaluation, diagnosis, and treatment of FPC.
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Affiliation(s)
- Tracy Lowe
- School of Nursing, Clemson University, Clemson, SC, 29634, USA.
- , Clemson, USA.
| | - Jane DeLuca
- School of Nursing, Clemson University, Clemson, SC, 29634, USA
| | - Ludovico Abenavoli
- Gastroenterology, Department of Health Sciences, University Magna Graecia, 88100, Catanzaro, Italy
| | - Luigi Boccuto
- School of Nursing, Clemson University, Clemson, SC, 29634, USA
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Goldberg JI, Flynn JR, Baser RE, Nelson JE, Capezuti E, Schulman-Green D. Exploring the Relationship Between Health-Illness Transition Experiences and Distress Among Patients With Pancreatic Cancer. Oncol Nurs Forum 2023; 50:625-633. [PMID: 37677764 PMCID: PMC10825807 DOI: 10.1188/23.onf.625-633] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/09/2023]
Abstract
OBJECTIVES To explore the correlation between health-illness transition (HIT) experiences and distress among patients with pancreatic cancer. SAMPLE & SETTING 55 patients with a diagnosis of pancreatic cancer receiving chemotherapy at a tertiary cancer center in New York. METHODS & VARIABLES A prospective correlational study was performed to explore the frequency, extent, and management of HITs. HITs were evaluated using the Measurement of Transitions in Cancer Scale, and distress was measured with the National Comprehensive Cancer Network Distress Thermometer. RESULTS All patients experienced at least one HIT. The extent of HITs decreased over time. Patients reported that they managed HITs moderately well. There was a significant correlation between unmanaged HITs and distress. As distress increased, the extent of the physical and emotional HITs increased and management worsened. IMPLICATIONS FOR NURSING HITs are ubiquitous among patients diagnosed with pancreatic cancer. Associated distress inhibits management. Nurses are well suited to assess for potential HITs and to support self-management of HITs.
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Martin D, Alberti P, Wigmore SJ, Demartines N, Joliat GR. Pancreatic Cancer Surgery: What Matters to Patients? J Clin Med 2023; 12:4611. [PMID: 37510726 PMCID: PMC10380608 DOI: 10.3390/jcm12144611] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/03/2023] [Revised: 06/28/2023] [Accepted: 07/08/2023] [Indexed: 07/30/2023] Open
Abstract
Pancreatic cancer is a leading cause of cancer-related death, with a poor overall survival rate. Although certain risk factors have been identified, the origins of pancreatic cancer are still not fully understood. Surgical resection remains the primary curative treatment, but pancreatic surgery is still associated with high morbidity and mortality rates, and most patients will experience recurrence. The impact of pancreatic cancer on patients' quality of life is significant, with an important loss of healthy life in affected individuals. Traditional outcome parameters, such as length of hospital stay, do not fully capture what matters to patients during recovery. Patient-centered care is therefore central, and the patient's perspective should be considered in pre-operative discussions. Patient-reported outcome and experience measures (PROMs and PREMs) could play an important role in assessing patient perspectives, but standardized methodology for evaluating and reporting them is needed. This narrative review aims to provide a comprehensive overview of patient perspectives and different patient-reported measures in pancreatic cancer surgery. Understanding the patient perspective is crucial for delivering patient-centered care and improving outcomes for patients with pancreatic cancer.
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Affiliation(s)
- David Martin
- Department of Visceral Surgery, University Hospital CHUV, University of Lausanne (UNIL), 1005 Lausanne, Switzerland
- Department of Surgery, Hepatobiliary and Pancreatic Unit, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK
| | - Piero Alberti
- Department of Surgery, Hepatobiliary and Pancreatic Unit, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK
| | - Stephen J Wigmore
- Department of Surgery, Hepatobiliary and Pancreatic Unit, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK
| | - Nicolas Demartines
- Department of Visceral Surgery, University Hospital CHUV, University of Lausanne (UNIL), 1005 Lausanne, Switzerland
| | - Gaëtan-Romain Joliat
- Department of Visceral Surgery, University Hospital CHUV, University of Lausanne (UNIL), 1005 Lausanne, Switzerland
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Pacheco-Barcia V, Gomez D, Obispo B, Mihic Gongora L, Hernandez San Gil R, Cruz-Castellanos P, Gil-Raga M, Villalba V, Ghanem I, Jimenez-Fonseca P, Calderon C. Role of sex on psychological distress, quality of life, and coping of patients with advanced colorectal and non-colorectal cancer. World J Gastrointest Oncol 2022; 14:2025-2037. [PMID: 36310711 PMCID: PMC9611434 DOI: 10.4251/wjgo.v14.i10.2025] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/25/2022] [Revised: 05/24/2022] [Accepted: 08/25/2022] [Indexed: 02/05/2023] Open
Abstract
BACKGROUND Patients with advanced gastrointestinal cancer must cope with the negative effects of cancer and complications.
AIM To evaluate psychological distress, quality of life, and coping strategies in patients with advanced colorectal cancer compared to non-colorectal cancer based on sex.
METHODS A prospective, transversal, multicenter study was conducted in 203 patients; 101 (50%) had a colorectal and 102 (50%) had digestive, non-colorectal advanced cancer. Participants completed questionnaires evaluating psychological distress (Brief Symptom Inventory-18), quality of life (EORTC QLQ-C30), and coping strategies (Mini-Mental Adjustment to Cancer) before starting systemic cancer treatment.
RESULTS The study included 42.4% women. Women exhibited more depressive symptoms, anxiety, functional limitations, and anxious preoccupation than men. Patients with non-colorectal digestive cancer and women showed more somatization and physical symptoms than subjects with colorectal cancer and men. Men with colorectal cancer reported the best health status.
CONCLUSION The degree of disease acceptance in gastrointestinal malignancies may depend on sex and location of the primary digestive neoplasm. Future interventions should specifically address sex and tumor site differences in individuals with advanced digestive cancer.
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Affiliation(s)
- Vilma Pacheco-Barcia
- Department of Medical Oncology, School of Medicine, Alcala University (UAH), Hospital Central de la Defensa Gómez Ulla, Madrid 28047, Spain
| | - David Gomez
- Department of Medical Oncology, Hospital Universitario de Navarra, Pamplona 31008, Spain
| | - Berta Obispo
- Department of Medical Oncology, Hospital Universitario Infanta Leonor, Madrid 28031, Spain
| | - Luka Mihic Gongora
- Department of Medical Oncology, Hospital Universitario Central de Asturias, Oviedo 33011, Spain
| | | | | | - Mireia Gil-Raga
- Department of Medical Oncology, Hospital General Universitario de Valencia, CIBERONC, Valencia 46014, Spain
| | - Vicente Villalba
- Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Barcelona, Barcelona 08007, Spain
| | - Ismael Ghanem
- Department of Medical Oncology, Hospital Universitario La Paz, Madrid 28046, Spain
| | - Paula Jimenez-Fonseca
- Department of Medical Oncology, Hospital Universitario Central de Asturias, ISPA, Oviedo 33007, Spain
| | - Caterina Calderon
- Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona 08007, Spain
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Liu Y, Liu W, Ma Y, Yang X, Zhou H, Zhang T, Shao S. Research on body image cognition, social support and illness perception in breast cancer patients with different surgical methods. Front Psychol 2022; 13:931679. [PMID: 36211874 PMCID: PMC9540219 DOI: 10.3389/fpsyg.2022.931679] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/29/2022] [Accepted: 08/29/2022] [Indexed: 11/13/2022] Open
Abstract
In parallel with the rapid rise in breast cancer incidence, there is also a noticeable rise in the number of patients who experience persistent negative body image cognition after breast cancer surgery. This study aimed to explore the differences in illness perception, social support, and body image cognition among breast cancer patients with different surgical methods, and the correlation, regression, and mediation among the three variables. The Brief Illness Perception Questionnaire (BIPQ), the Social Support Rating Scale (SSRS) and the Body Image Cognition after Breast Cancer Questionnaire (BIBCQ) were used to evaluate breast cancer patients’ illness perception, social support and body image cognition. Data analyses were performed by descriptive statistics, independent samples t-test, analysis of variance (ANOVA), Pearson correlation, and linear regression. The mediation was explored by the PROCESS V3.3. The study found that breast cancer patients undergoing radical mastectomy (RM) and modified radical mastectomy (MRM) demonstrated more negative illness perception, body image cognition, and lower social support compared with the patients receiving nipple-sparing mastectomy (NSM; p < 0.05). The subscale cognitive representation (CR) of BIPQ was strongly positively correlated with BIBCQ (p < 0.05). Illness perception positively predicted body image cognition (p < 0.01), while social support negatively predicted body image cognition. Social support partially mediated illness perception and body image cognition, exhibiting a positive role in post-operative body image cognition.
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Affiliation(s)
- Yuhan Liu
- Department of Medical Psychology, Binzhou Medical University, Yantai, Shandong, China
- The First School of Clinical Medicine of Binzhou Medical University, Binzhou, Shandong, China
| | - Wanli Liu
- Department of Medical Psychology, Binzhou Medical University, Yantai, Shandong, China
| | - Yinglu Ma
- Department of Breast Surgery, Binzhou Medical University Hospital, Binzhou, Shandong, China
| | - Xiaoyue Yang
- Department of Medical Psychology, Binzhou Medical University, Yantai, Shandong, China
| | - Han Zhou
- Department of Psychology, Binzhou Medical University Hospital, Binzhou, Shandong, China
| | - Tingting Zhang
- Department of Medical Psychology, Binzhou Medical University, Yantai, Shandong, China
| | - Shuhong Shao
- Department of Medical Psychology, Binzhou Medical University, Yantai, Shandong, China
- *Correspondence: Shuhong Shao,
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Abstract
ABSTRACT Pain is a subjective experience and its perception and expression vary widely. Pain catastrophizing, which refers to patients' thoughts or feelings about their pain, may impact their communication of pain and nurses' subsequent response. This article discusses how nurses can more readily recognize, assess, and manage pain catastrophizing.
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Affiliation(s)
- Osheeca J Thompson
- Osheeca Thompson is a clinical research coordinator at the University of Florida (UF) College of Medicine. Keesha Powell-Roach is an assistant professor at the University of Tennessee Health Science Center College of Nursing. Janiece Taylor is an assistant professor on the research/education track at the Johns Hopkins School of Nursing. Ellen Terry and Staja Booker are assistant professors at UF's College of Nursing and the Pain Research and Intervention Center of Excellence in the College of Dentistry
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Choudhury T, Arunachalam R, Khanna A, Jasinska E, Bolshev V, Panchenko V, Leonowicz Z. A Social Network Analysis Approach to COVID-19 Community Detection Techniques. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:ijerph19073791. [PMID: 35409474 PMCID: PMC8997780 DOI: 10.3390/ijerph19073791] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 01/27/2022] [Revised: 03/14/2022] [Accepted: 03/19/2022] [Indexed: 02/04/2023]
Abstract
Machine learning techniques facilitate efficient analysis of complex networks, and can be used to discover communities. This study aimed use such approaches to raise awareness of the COVID-19. In this regard, social network analysis describes the clustering and classification processes for detecting communities. The background of this paper analyzed the geographical distribution of Tambaram, Chennai, and its public health care units. This study assessed the spatial distribution and presence of spatiotemporal clustering of public health care units in different geographical settings over four months in the Tambaram zone. To partition a homophily synthetic network of 100 nodes into clusters, an empirical evaluation of two search strategies was conducted for all IDs centrality of linkage is same. First, we analyzed the spatial information between the nodes for segmenting the sparse graph of the groups. Bipartite The structure of the sociograms 1–50 and 51–100 was taken into account while segmentation and divide them is based on the clustering coefficient values. The result of the cohesive block yielded 5.86 density values for cluster two, which received a percentage of 74.2. This research objective indicates that sub-communities have better access to influence, which might be leveraged to appropriately share information with the public could be used in the sharing of information accurately with the public.
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Affiliation(s)
- Tanupriya Choudhury
- Informatics Cluster, School of Computer Science, University of Petroleum and Energy Studies (UPES), Dehradun 248007, India
- Correspondence: (T.C.); (V.B.); Tel.: +91-9711938087 (T.C.); +7-499-174-85-95 (V.B.)
| | - Rohini Arunachalam
- Miracle Educational Society Group of Institutions, ViziaNagaram 535216, Andhra Pradesh, India;
| | - Abhirup Khanna
- Systemics Cluster, School of Computer Science, University of Petroleum and Energy Studies (UPES), Dehradun 248007, India;
| | - Elzbieta Jasinska
- Department of Operations Research and Business Intelligence, Wrocław University of Science and Technology, 50-370 Wroclaw, Poland;
| | - Vadim Bolshev
- Federal Scientific Agroengineering Center VIM, 109428 Moscow, Russia;
- Correspondence: (T.C.); (V.B.); Tel.: +91-9711938087 (T.C.); +7-499-174-85-95 (V.B.)
| | - Vladimir Panchenko
- Federal Scientific Agroengineering Center VIM, 109428 Moscow, Russia;
- Department of Theoretical and Applied Mechanics, Russian Open Academy of Transport, 125315 Moscow, Russia
| | - Zbigniew Leonowicz
- Faculty of Electrical Engineering, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland;
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Piotrkowska R, Sanecka N, Mędrzycka-Dąbrowska W, Jarzynkowski P. Beliefs about Pain Control in Patients after Abdominal Aortic Aneurysm Surgery-A Preliminary Study. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:ijerph19063708. [PMID: 35329395 PMCID: PMC8951241 DOI: 10.3390/ijerph19063708] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Received: 01/03/2022] [Revised: 03/15/2022] [Accepted: 03/18/2022] [Indexed: 12/04/2022]
Abstract
Introduction: Pain-control beliefs significantly influence the perception of disease and, therefore, may influence the treatment outcomes of surgical patients. The sense of control is related to the sense of agency and the ability to influence one’s own life and environment. This construct may be external or internal. The belief that pain control depends on internal or external factors can depend on many variables. This may be influenced by socio-demographic and clinical characteristics, as well as the source and cause of pain. The aim of the study was the assessment of the relationship between the intensity of postoperative pain and beliefs about pain control in patients after AAA surgery and assessment of the relationship between socio-demographic and clinical variables and beliefs about pain control in patients after AAA surgery. Materials and Methods: The research material consisted of 42 patients aged 57 to 85, hospitalized at the Department of Cardiac Surgery and Vascular Surgery of the University Clinical Center in Gdańsk. The research was conducted from March to September 2020. The study uses a survey technique based on a standardized research tool: the Polish version of the BPCQ (The Beliefs about Pain Control Questionnaire), the NRS (Numerical Rating Scale), and the author’s own questionnaire that allows for the collection of socio-demographic data. Results: The highest intensity of pain was observed in subjects with ruptured AAA H (2) = 6.19; p < 0.05 and subjects who underwent classic surgery Z = −2.95; p < 0.05 (non-parametric Mann−Whitney U test). Subjects with ruptured aneurysms are less convinced about the influence of internal factors on pain control H (2) = 5.26; p < 0.05. The respondents’ conviction about the influence of doctors on pain control increased together with their age, rHO = 0.38, p < 0.05. Conclusion: Pain intensity after surgery did not significantly correlate with beliefs about pain control. Patients with ruptured AAA are less convinced about the influence of internal factors on pain control. With age, patients have more confidence in their doctors than in themselves to control their pain.
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Affiliation(s)
- Renata Piotrkowska
- Department of Surgical Nursing, Medical University of Gdansk, Debinki 7, 80-211 Gdańsk, Poland;
- Correspondence:
| | - Natalia Sanecka
- Clinic of Cardiac and Vascular Surgery, University Clinical Centre, 80-952 Gdańsk, Poland;
| | - Wioletta Mędrzycka-Dąbrowska
- Department of Anaesthesiology Nursing and Intensive Care, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland;
| | - Piotr Jarzynkowski
- Department of Surgical Nursing, Medical University of Gdansk, Debinki 7, 80-211 Gdańsk, Poland;
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Du X, Jiang H, Fu L, Wang A. Development and validation of a self-management behavior questionnaire for Chinese enterostomy patients. Int J Nurs Sci 2022; 9:252-258. [PMID: 35509691 PMCID: PMC9052256 DOI: 10.1016/j.ijnss.2022.03.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/13/2022] [Revised: 02/21/2022] [Accepted: 03/07/2022] [Indexed: 11/15/2022] Open
Abstract
Objectives This study aimed to develop a self-management behavior questionnaire for Chinese enterostomy patients and examine its reliability and validity. Methods Guided by the theory of self-management, an initial questionnaire was generated through literature review, group meetings, and two rounds of an expert consultation. Finally, the reliability and validity of the questionnaire were validated through a questionnaire survey of 200 enterostomy patients were selected from the Affiliated Hospital of Medical University from June 2016 to March 2017. Results The content validity index was 0.80–1.00. The exploratory factor analysis yielded a five-factor (dietary behavior, psychosocial behavior, symptom management behavior, medical compliance behavior, information management behavior), consisting of 40 items. The cumulative variance contribution rate was 65.42%. The Cronbach’s α coefficient for the total questionnaire was 0.972, and for the five factors ranged from 0.797 to 0.939, indicating a good internal consistency. The test-retest reliability was 0.867 (P < 0.01). The self-management behavior questionnaire score was negatively related to the Ostomy Skin Tool score (r = −0.800, P < 0.01). Conclusions The self-management behavior questionnaire developed in this study showed good reliability and validity and can be used to assess the self-management behavior of Chinese enterostomy patients.
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Liu L, Li Y, Zhang X, Zhang H. The correlation of the miR-29a/MMP9 axis with Helicobacter pylori infection in gastric cancer. Am J Transl Res 2021; 13:10155-10162. [PMID: 34650687 PMCID: PMC8506987] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/07/2021] [Accepted: 08/08/2021] [Indexed: 06/13/2023]
Abstract
OBJECTIVE This study was designed to investigate the association between the miR-29a/MMP9 axis expression levels and Helicobacter pylori (HP) infection in gastric cancer patients. METHODS A total of 100 gastric cancer patients referred to our hospital from June 2017 to June 2019 were recruited as the study cohort. Among them, 50 HP-positive patients were included in the experimental group and 50 HP-negative patients were included in the control group. The changes in the patients' conditions were compared, the miR-29a/MMP9 axis expression levels were recorded, and the correlation between the miR-29a/MMP9 axis and the HP infections was analyzed. All the discharged patients were followed up for one year to analyze the correlation between the HP infections and the serum miR-29a and MMP9 expression levels with the disease progression. RESULTS The experimental group had higher miR-29a expression levels and higher MMP9 chromogenic scores than the control group (P<0.05). A negative correlation was found between the miR-29 expression level and the MMP9 expression level (r=-5.369, P<0.05). One year after discharge, there were 27 patients with severe disease in the experimental group and 6 in the control group, with a significant difference between the two groups. Moreover, the expression levels of the miR-29a/MMP9 axis were significantly higher in the discharged patients than in the patients with severe disease (P<0.05). A receiver operating characteristic (ROC) curve was used to analyze the predictive value of miR-29/MMP9 in the diagnosis of gastric cancer, and the area under the curve was found to be 0.97. CONCLUSION The miR-29a/MMP9 axis levels were increased in the HP positive patients but not in the HP negative patients. HP infection is considered to be closely related to gastric cancer cell spread, disease relapse, and high miR-29a/MMP9 axis expression levels.
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Affiliation(s)
- Lunqin Liu
- Shandong Public Health Clinical CenterJinan, Shandong Province, China
| | - Yuecui Li
- Maternal and Child Health HospitalZhangqiu District, Jinan, Shandong Province, China
| | - Xia Zhang
- Maternal and Child Health HospitalZhangqiu District, Jinan, Shandong Province, China
| | - Hong Zhang
- The Sixth People’s Hospital of JinanJinan, Shandong Province, China
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Tao HL, Shen HY, Wang D. Psychological effects of individual computer games and story-version magnanimous-relaxing therapy in patients with rectal cancer surgery. Shijie Huaren Xiaohua Zazhi 2021; 29:256-264. [DOI: 10.11569/wcjd.v29.i5.256] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/06/2023] Open
Abstract
BACKGROUND Computer games and story-version magnanimous-relaxing therapy are currently emerging psychological counseling techniques. Computer games can relax the mind while diverting the patient's attention. The story-version magnanimous-relaxing therapy can penetrate the open-minded relaxation theory into the subconscious and cultivate habitual psychological behaviors, which has positive significance in helping individuals maintain an open-minded mood and a state of full-body relaxation.
AIM To explore the psychological effect of individual computer games and story-version magnanimous-relaxing therapy in patients with rectal cancer surgery.
METHODS From January 2018 to June 2020, 96 patients who underwent rectal cancer surgery at our hospital were selected. According to the order of admission, they were equally divided into either a control group or an observation group. Both groups were given routine intervention, and the observation group was additionally given individual computer games and story-version magnanimous-relaxing therapy. The open-minded psychology, Cancer Coping Modes Questionnaire (CCMQ), self-perceived burden scale for cancer patients (SPBS-CP), Piper fatigue scale (PFS), and physiological fluctuation indicators (diastolic blood pressure, systolic blood pressure, and heart rate) at admission, 1 d before surgery, and 4 wk after surgery were compared between the two groups.
RESULTS The scores of open-mindedness, tolerance, and aggressiveness in the observation group at 1 d before surgery and 4 wk after surgery were significantly higher than those of the control group (P ＜ 0.05). The score of face was significantly higher and the scores of yield, avoidance, and depression were significantly lower in the observation group than in the control group at 1 d before surgery and 4 wk after surgery (P ＜ 0.05). The diastolic blood pressure, systolic blood pressure, and heart rate at 1 d before surgery and 4 wk after surgery were significantly lower in the observation group than in the control group (P ＜ 0.05). The carcinogenic fatigue scores of the observation group in the dimensions of behavior, emotion, and perception at 1 d before surgery and 4 wk after surgery were significantly lower than those of the control group (P ＜ 0.05). The body burden, emotional burden, and economic burden of the observation group at 1 d before surgery and 4 wk after surgery were significantly lower than those of the control group (P ＜0.05).
CONCLUSION In the nursing of patients undergoing rectal cancer surgery, the combination of individual computer games and story-version magnanimous-relaxing therapy can improve patients' psychological adjustment ability and psychological coping ability, and help reduce patients' cancer-related fatigue, relieve self-perceived burden, and reduce the fluctuation of patients' physiological indicators.
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Affiliation(s)
- Hang-Ling Tao
- Department of General Surgery, Hangzhou Ninth People's Hospital, Hangzhou 311225, Zhejiang Province, China
| | - Hong-Yan Shen
- Department of General Surgery, Hangzhou Ninth People's Hospital, Hangzhou 311225, Zhejiang Province, China
| | - Dan Wang
- Department of General Surgery, Hangzhou Ninth People's Hospital, Hangzhou 311225, Zhejiang Province, China
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