Management of liver transplantation biliary stricture: Results from a tertiary hospital

Table 1 Summary of patients characteristics

	Multiple plastic stents	cSEMS
n	109	48
Sex
Male	76 (69.7%)	36 (75.0%)
Female	33 (30.3%)	12 (25.0%)
Age (yr)
Mean (± SD)	48.8 (± 14.5)	54.5 (± 12.9)
Median	50	56.8
Range	10-75	17-73
Time of anastomotic stricture after orthotopic liver transplantation (d)
Mean (± SD)	214.2 (± 411.4)	221.6 (± 263.3)
Median	72	115.5
Range	6-2663	8-1339
Hepatic artery associated lesions
Stenosis	3 (2.8%)	3 (6.3%)
Thrombosis	8 (7.3%)	1 (2.1%)
Associated biliary lesions
Anastomotic fistula	5 (4.6%)	2 (4.2%)
Non-anastomotic fistula	1 (0.9%)	0 (0.0%)
Non-anastomotic stricture	1 (0.9%)	0 (0.0%)
Cholangitis	2 (1.8%)	0 (0.0%)
Stones	2 (1.8%)	0 (0.0%)

cSEMS: Covered self-expandable metal stents.

Table 2 Summary of treatment characteristics n (%)

	Multipleplastic stents	cSEMS
Total number of ERCP	271	70
Stent treatment duration (d)
Mean (± SD)	282.7 (± 135.4)	124.2 (± 67.9)
Median	322	107.5
Range	3-767	9-269
Number of ERCP per patient
Mean (± SD)	3.9 (± 1.5)	2.0
Median	4	2.0
Range	1-7	-
Number of stents per ERCP session
Mean (± SD)	2.9 (± 1.5)	1
Median	3.0	1
Range	1-10	-
Total number of stents per patient
Mean (± SD)	10.0 (± 7.2)	1
Median	10	1
Range	1-30	-
Complications	26 (9.6)	17 (24.3)
Acute pancreatitis	11 (4.1)	12 (17.1)
Bleeding	7 (2.6)	0 (0.0)
Perforation	2 (0.7)	0 (0.0)
Cardiorespiratory	2 (0.7)	0 (0.0)
Bacteremia	4 (1.4)	1 (1.4)
Pain	0 (0.0)	4 (5.7)
Stent related complications
Migration	15 (5.5)	3 (4.3)
Occlusion	5 (1.8)	0 (0.0)

cSEMS: Covered self-expandable metal stents; ERCP: Endoscopic retrograde cholangiopancreatographys.

Table 3 Summary of the patients outcomes n (%)

	Multiple plastic stents	cSEMS
n	100	38
Stricture resolution rate
Success	91 (91.0)	33 (86.8)
Failure	9 (9.0)	5 (13.2)
Follow-up (d)
Mean (± SD)	690.8 (± 632.6)	620.3 (± 540.7)
Median	538	479
Range	0-2823	0-1615
Recurrence rate	7 (7.7)	10 (30.3)
Time to recurrent anastomotic stricture (d)
Mean (± SD)	296.9 (± 259.5)	310.0 (± 348.4)
Median	240	124
Range	73-667	27-975
Re-treatment after failure or recurrent anastomotic stricture
Success	10 (62.5)	10 (66.6)
Failure	6 (37.5)	1 (6.7)
In treatment	0 (0.0)	3 (20.0)
Lost of follow-up	0 (0.0)	1 (6.7)

cSEMS: Covered self-expandable metal stents.