Retrospective Study
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastrointest Endosc. Aug 16, 2014; 6(8): 359-365
Published online Aug 16, 2014. doi: 10.4253/wjge.v6.i8.359
Table 1 Summary of results
Angioectasias (n = 39)Ulcers/erosions (n = 49)Villous edema/atrophy (n = 12)Overall (n = 100)
FICE 1
Improved delineation38/39 (97.4%)31/49 (63.3%)8/12 (66.7%)77/100 (77.0%)
Percentage of agreement, κ97.4%, κ = 0.91081.6%, κ = 0.71491.7%, κ = 0.81589.0%, κ = 0.833
FICE 2
Improved delineation38/39 (97.4%)28/49 (57.1%)8/12 (66.7%)74/100 (74.0%)
Percentage of agreement, κ89.7%, κ = 0.80279.6%, κ = 0.70391.7%, κ = 0.81585.0%, κ = 0.764
FICE 3
Improved delineation18/39 (46.2%)12/49 (24.5%)0/12 (0.0%)41/100 (41.0%)
Percentage of agreement, κ53.8%, κ = NA75.5%, κ = NA66.7%, κ = 0.30466.0%, κ = 0.486
BF
Improved delineation6/39 (15.4%)30/49 (61.2%)3/12 (25.0%)39/100 (39.0%)
Percentage of agreement, κ76.9%, κ = 0.55881.6%, κ = 0.57025.0%, κ = NA79.0%, κ = 0.593
Table 2 Summary of publications on small bowel capsule endoscopy-virtual chromoendoscopy
Ref.CenterStudy typeNo. of patientsOutcomeResults
Imagawa et al[7]Single centerRetrospective122 patientsDelineation145 lesions
FICE 1: improved delineation in 87.0% (20/23) of angioectasias, 53.3% (26/47) of ulcers/erosions and 25.3% (19/75) of tumors
FICE 2: improved delineation in 87.0% (20/23) of angioectasias, 25.5% (12/47) of ulcers/erosions and 20.0% (15/75) of tumors
FICE 3: no improvement
Imagawa et al[6]Single centerProspective50 patientsDetection rateFICE 1: increased detection rate of angioectasias (48 vs 17, P = 0.0003)
FICE 2: increased detection rate of angioectasias (45 vs 17, P < 0.0001)
FICE 3: increased detection rate of angioectasias (24 vs 17, P = ns)
Detection of ulcers, erosions and tumors did not differ significantly between conventional SBCE-WL and SBCE-FICE
Gupta et al[22]Single centerRetrospective60 patientsDetection rate157 lesions detected with SBCE-FICE vs 114 with SBCE-WL (P = 0.15)
5/55 angioectasias were better characterized with SBCE-FICE
More P0 diagnosed with SBCE-FICE (39 vs 8, P < 0.001)
Intra-class κ correlations with SBCE-FICE: 0.88 (P2 lesions); 0.61 (P1 lesions)
Intra-class κ correlations with SBCE-WL: 0.92 (P2 lesions); 0.79 (P1 lesions)
For P2 lesions, the sensitivity was 94% vs 97% and specificity was 95% vs 96% for SBCE-FICE and SBCE-WL, respectively
Krystallis et al[19]Single centerRetrospective200 patientsDelineation167 lesions including angioectasias (n = 18), erosions/ulcers (n = 60), villi oedema (n = 17), cobblestone (n = 11), blood lumen (n = 15), lesions of unknown clinical significance (n = 46)
FICE 1: improved delineation in 34%; κ = 0.646
FICE 2: improved delineation in 8.6%; κ = 0.617
FICE 3: improved delineation in 7.7%; κ = 0.669
Blue mode: improved delineation in 83%; κ = 0.786
Duque et al[8]Single centerProspective20 patientsDetection rate150 lesions
SBCE-FICE: increased detection rate (95 vs 75), κ = 0.650
SBCE-FICE did not miss any lesion identified by CE-WL and allowed the identification of a higher number of angioectasias (35 vs 32, P = 0.25) and erosions (41 vs 24, P < 0.001)
Nakamura et al[25]Single centerProspective50 patientsDetection rate (QuickView)SBCE-WL: sensitivity 80%, specificity 100%
SBCE-FICE: sensitivity 91% specificity 86%
SBCE-FICE resulted in more false positive findings and lower specificity
Sakai et al[26]Single centerProspective12 patientsDetection rate142 lesions including angioectasias (n = 60) and ulcers/erosions (n = 82)
Angioectasias were detected with CE-WL (26/60), SBCE-FICE 1 (40/60), SBCE-FICE 2 (38/60), SBCE-FICE 3 (31/60)
Ulcers/erosions were detected with SBCE-WL (38/82), SBCE-FICE 1 (62/82), SBCE-FICE 2 (60/82), SBCE-FICE 3 (20/82)
SBCE-FICE 1and 2 significantly increased the detection rate of angioectasias (P = 0.0017 and P = 0.014, respectively) and ulcers/erosions (P = 0.0012 and P = 0.0094, respectively)
In poor bowel visibility conditions, SBCE-FICE yielded a high rate of false-positive findings
Cotter et alSingle centerRetrospective49 patientsDelineation100 lesions including angioectasias (n = 39), ulcers/erosions (n = 49), villous edema/atrophy (n = 12)
FICE 1: image improvement in 77% (κ = 0.833)
FICE 2: image improvement in 74% (κ = 0.764)
FICE 3: image improvement in 66% (κ = 0.486)
BF: image improvement in 79% (κ = 0.593)
FICE 1 improved the delineation of 97.4% of angioectasias, 63.3% of ulcers/erosions and 66.7% of villous edema/atrophy
FICE 2 improved the delineation of 97.4% of angioectasias, 57.1% of ulcers/erosions and 66.7% of villous edema/atrophy
FICE 3 improved the delineation of 46.2% of angioectasias, 24.5% of ulcers/erosions and none of the cases of villous edema/atrophy
BF improved the delineation of 15.4% of angioectasias, 61.2% of ulcers/erosions and 25.0% of villous edema/atrophy