Photodynamic therapy: Palliation and endoscopic technique in cholangiocarcinoma

Table 1 Table comparing studies performed by using endoscopic retrograde cholangiopancreatography with photodynamic therapy with photofrin sodium for palliation of cholangiocarcinoma

Study	Year	N	Study type	Median TB before and after PDT	Mean PDT sessions (range)	Median survival (mo)	Adverse events phototoxicity, cholangitis n (%)
Ortner et al[62]	1998	9	Single Arm	18.6 > 6	1.5 (1-2)	14.6	1 (11), 0 (0)
Berr et al[62]	2000	23	Single Arm	11.2 > 1.1	3.0 (1-5)	11.1	3 (13), 8 (35)
Rumalia et al[63]	2001	6	Single Arm	2.7 > 1.3	2.3 (1-2)	> 6	2 (33), 2 (33)
Dumoulin et al[64]	2003	24	Single Arm	13.3 > 2.6	1-2	9.9	2 (8), 5 (21)
Ortner et al[52]	2003	20	Randomized	NA (decreased)	2.4 (1-5)	16.4	2 (10), 5 (25)
Ortner et al[52]	2003	31	Nonrandomized	11.8 > 3.1	1.5 (1-4)	14.2	3 (10), 6 (19)
Harewood et al[65]	2005	8	Single Arm	7.7 > 1.1	2.0 (1-5)	9.2	2 (25), 2 (25)
Witzigmann et al[66]	2006	68	Single Arm	NA (decreased)	2.0 (1-6)	12.0	8 (12), 38 (56)
Prasad et al[61]	2007	25	Single Arm	6.1 > 3.5	1.6 (1-4)	13.4	1 (4), 2 (8)
Kahaleh et al[58]	2008	19	Comparative	6.3 > 3.5	1.6 (1-3)	16.2	3 (16), 7 (37)

TB: total bilirubin; NA: not available; PDT: photodynamic therapy.