Propofol sedation in routine endoscopy: A case series comparing target controlled infusion vs manually controlled bolus concept

Table 1 Endoscopy list [n (%)]

Endoscopy	Bolus (n = 80)	TCI (n = 45)
Gastroscopy	7 (8.7)	3 (6.6)
Colonoscopy	18 (22.5)	9 (20.0)
Gastro/Colo	30 (37.5)	18 (40.0)
EUS	20 (25.0)	12 (26.7)
ERCP	5 (6.3)	3 (6.7)

TCI: Target controlled infusion; EUS: Endosonography ; ERCP: Endoscopic retrograde cholangiopancreatography.

Table 2 Number and percentage of adverse events [n (%)]

	Bolus (n = 80)	TCI (n = 45)	P value
Total adverse events	21 (26.0)	11 (24.0)	0.95
Hypoxemia	3 (14.4)	4 (36.4)
Hypotension	10 (47.6)	5 (45.4)
Bradycardia	4 (19.0)	2 (18.2)
Tachycardia	4 (19.0)	0

TCI: Target controlled infusion.

Table 3 Subgroup analysis according to duration of endoscopy: Short endoscopy < 30 min

Variable (mean ± SD)	Bolus (n = 21)	TCI (n = 10)	Delta	P value
Induction time (min)	4.81 ± 1.67	5.8 ± 1.81	0.99	0.11
Total time (min)	20.62 ± 6.49	21 ± 4.71	0.38	0.65
Total dose (mg)	198.1 ± 69.19	204.4 ± 74.23	6.3	0.81
Dose/time (mg/min)	10.14 ± 3.25	9.87 ± 3.58	0.27	0.58

TCI: Target controlled infusion.

Table 4 Subgroup analysis according to duration of endoscopy: Long endoscopy > 60 min

Variable (mean ± SD)	Bolus (n = 13)	TCI (n = 9)	Delta	P value
Induction time (min)	6.08 ± 5.15	9.44 ± 3.50	3.36	< 0.01
Total time (min)	73.30 ± 14.29	69.89 ± 8.95	3.41	0.89
Total dose (mg)	656.15 ± 291.42	484.67 ± 200.02	71.48	0.27
Dose/time (mg/min)	8.94 ± 3.21	6.82 ± 2.44	2.12	0.08

TCI: Target controlled infusion.