Peroral endoscopic myotomy: An emerging minimally invasive procedure for achalasia

Table 2 Reported outcomes for Large Volume Single Centers after peroral endoscopic myotomy

Ref.	Study size	Myotomy thicknes/length	Morbidity	Follow up(mo)	Clinical outcome - before/after	Manometry before/after	Postop PPI
Inoue et al[14] 2013	300	Partial	Pneumothorax 0.3%	12	Eckardt - 6.13/1.33	27.3/13.4	4.9%
		14.1 cm	Mucosal Injury - 2.0%		98.2% success
Ren et al[10] 2012	119	Partial	Pneumothorax - 25.2%	3	98.3% success	NA	NA
		9.2 cm	Pneumoperitoneum - 39.5% Bleeding 0.8%
Friedel et al[15] 2013	45	Full	Mucosal Injury - 20%	3	Eckardt - 7.8/0.4	NA	NA
		9 cm	Pneumoperitoneum - 13%		95% success
Bhayani et al[9] 2014	37	Partial	Perforation - 10.8% Bleeding - 2.7%	6.8	Eckardt - 5.4/1.2	41/16	NA
					Dysphagia - 0%
Vigneswaran et al[17] 2014	37	Partial	Perforation - 5.4%	11.3	Eckardt - 6.8/0.6	29.1/NA	22%
		12.8 cm	Mucosal Injury - 2.7%		100% success
Hungness et al[12] 2013	18	Partial	Perforation - 5.6%	6	Eckardt - 7/1	19/9	NA
		9 cm			89% success
von Renteln et al[7] 2012	16	Partial and full	Perforation - 0%	3	Eckardt - 8.8/1.4	27.2/11.8	6.3%
		12 cm	Pneumoperitoneum - 50%		94% success

NA: Not available; PPI: Proton pump inhibitor.