Resection margin influences the outcome of patients with bilobar colorectal liver metastases

Table 1 Clinical data of patients with bilobar colorectal liver metastases in this study

Demographic, clinical and pathological factors	Total (n)
All patients (n = 136)
All surgery patients (n = 71)
Demographic factors
Age > 65 yr	68
Male gender	99
Synchronous presentation	80
Down-staging therapy	70
Oxaliplatin-based regimen	60
Irinotecan-based regimen	10
Addition of biological agent	30
Surgical factors (n = 71)
Hemi-hepatectomy or more	22
Histo-pathological factor (n = 71)
Largest tumour size ≥ 5 cm	11
Number of metastases < 4	44
Lymphatic invasion present	15
Vascular invasion present	28
Peri-neural invasion present	9
Biliary invasion present	25
Resection margin (R0)	40

Table 2 Statistical analysis of prognostic factors with respect to disease-free survival

Demographic, clinical and pathological factors	Survival [median (range) mo]	Uni-variate analysis
Demographic factors
Age		0.099
< 65 yr (n = 43)	6 (3-36)
≥ 65 yr (n = 28)	12 (2-36)
Gender		0.343
Male (n = 50)	6 (3-36)
Female (n = 21)	5 (2-36)
Presentation		0.755
Synchronous (n = 35)	6 (2-36)
Metachronous (n = 36)	6 (3-36)
Surgical factors
Less than hemi-hepatectomy (n = 49)	6 (2-36)	0.760
Hemi-hepatectomy or more (n = 22)	6 (2-36)
Histo-pathological factor
Largest tumour size		0.813
< 5 cm (n = 60)	6 (2-36)
≥ 5 cm (n = 11)	9 (2-36)
No. of metastases		0.538
< 4 (n = 44)	7 (2-36)
> 5 (n = 27)	6 (3-36)
Lymphatic invasion		0.256
Positive (n = 15)	6 (2-24)
Negative (n = 56)	6 (2-36)
Vascular invasion		0.775
Positive (n = 28)	6 (2-36)
Negative (n = 43)	7 (2-36)
Peri-neural invasion		0.115
Positive (n = 9)	6 (2-24)
Negative (n = 62)	6 (2-36)
Biliary invasion		0.919
Positive (n = 25)	6 (2-36)
Negative (n = 46)	6 (2-36)
Resection margin (R0)		0.017
R0 (n = 40)	8 (2-36)
R1 (n = 31)	6 (2-36)

Table 3 Statistical analysis of prognostic factors with respect to overall survival

Demographic, clinical and pathological factors	Survival [median (range) mo]	Uni-variate analysis	Multi-variate analysis	Risk ratio (confidence interval)
Demographic factors
Age		0.173
< 65 yr (n = 43)	20 (6-48)
≥ 65 yr (n = 28)	27 (7-48)
Gender		0.024	0.036	3.172 (1.079-9.327)
Male (n = 50)	19 (6-48)
Female (n = 21)	20 (11-48)
Presentation		0.932
Synchronous (n = 35)	23 (6-48)
Metachronous (n = 36)	24 (6-48)
Surgical factors
Less than hemi- hepatectomy (n = 49)	22 (6-48)	0.947
Hemi-hepatectomy or more (n = 22)	28 (7-48)
Histo-pathological factor
Largest tumour size		0.216
< 5 cm (n = 60)	24 (6-48)
≥ 5 cm (n = 11)	28 (12-48)
Number of metastases		0.674
< 4 (n = 44)	24 (6-48)
> 5 (n = 27)	24 (11-48)
Lymphatic invasion		0.943
Positive (n = 15)	24 (11-48)
Negative (n = 56)	23 (6-48)
Vascular invasion		0.367
Positive (n = 28)	25 (6-48)
Negative (n = 43)	23 (6-48)
Peri-neural invasion		0.220
Positive (n = 9)	12 (11-48)
Negative (n = 62)	24 (6-48)
Biliary invasion		0.608
Positive (n = 25)	27 (11-48)
Negative (n = 46)	22 (6-48)
Resection margin (R0)		0.022	0.030	0.403 (0.178-0.917)
R0 (n = 40)	24 (6-48)
R1 (n = 31)	22 (6-48)