Therapeutic and clinical aspects of portal vein thrombosis in patients with cirrhosis

Table 1 Studies on management of portal vein thrombosis in cirrhotic patients

Ref.	Study type	PVT	Number anticoagulate patients	Number controls	Typeanticoagulant	Duration anticoagulation	Repermeation/stabilization/progression of thrombosis in anticoagulate patients	Repermeation/stabilization/progression of thrombosis in control patients	Bleeding complications in anticoagulate patients	Bleeding complications in controls
Francoz et al[4]	Proscpective; Case control	29	19	10	VKA (target INR 2-3)	Mean 8.1 mo	8/10/1	0/4/6	1 variceal bleeding after EBL	NA
Amitrano et al[25]	Prospective	28	28	-	Enoxaparin 200 UI/kg per day	6 mo in repermeation, until end follow up in partial responders	21/5/2	-	1 anemia in PHG	-
Senzolo et al[24]	Prospective; Case control	56	35	21	Nadroparin 95 antiXa U/kg twice a day	6 mo after complete repermeation, until the end of follow up in other patients	21/7/5	1/5/15	1 variceal bleeding; 1 cerebral haemorrage; 1 haematuria; 1 epistaxis	5 variceal bleeding
Delgado et al[26]	Retrospective	55	55	-	VKA (8 patients); VKA → LMWH (21 patients); LMWH (26 patients)	Median 6.8 mo (range 1-56 mo)	33/22/0	-	6 variceal bleeding; 1 obscure gastrointestinal bleeding; 1 lower gastrointestinal bleeding; 1 oral bleeding after dental extraction	-

PVT: Portal vein thrombosis; VKA: Vitamin K antoagonists; LMWH: Low molecular weight heparin; NA: Not available; PHG: Portal hypertensive gastropathy; EBL: Endoscopic bend ligation; INR: Internatiol normalized ratio.