Review
Copyright ©The Author(s) 2015.
World J Hepatol. Dec 8, 2015; 7(28): 2819-2828
Published online Dec 8, 2015. doi: 10.4254/wjh.v7.i28.2819
Table 1 Newer weight reduction drugs in pipeline
DrugMechanism of action
CetilistatGastrointestinal and pancreatic lipase inhibitor
VelneperitNeuropeptide Y5 receptor inhibitor, appetite suppression
TesofensineInhibition of serotonin, dopamine, and noradrenaline reuptake
MetreleptinLeptin receptor agonist
ObinepitideDual neuropeptide Y2/Y4 receptor agonist
BeloranibMetAP2 inhibition
Table 2 Studies of bariatric surgery in cirrhotic patients
Ref.Study characteristicsCirrhosis diagnosisChild pughProceduresComplicationsLiver decompensationMortality
Pestana et al[74]Mean age = 55.5 yrKnown cirrhosisA = 14SG = 1101 (late HE)0
n = 14RYGB = 3
F:M = 10:4
Shimizu et al[73]Mean age = 51.5 yr12 preoperativelyA = 22RYGB = 14800
n = 23Mean BMI = 48.2 kg/m211 intraoperativelyB = 1SG = 8
F:M = 14:9Mean stay = 4.3 dAGB = 1
Rebibo et al[78]Median age = 52 yrAll intraoperativelyA = 13SG = 1321 (ascites)0
n = 13Median BMI = 46.3 kg/m2
F:M = 7:6
Takata et al[71]Mean age = 52 yrAll preoperativelyA = 4SG = 621 (ascites)0
n = 6Mean BMI = 49 kg/m2B = 21 (HE)
F:M = 4:2
Dallal et al[76]Mean age = 50 yrDiagnosed intraoperativelyA = 30RYGB = 27900
n = 30Mean BMI = 52.6 kg/m2in 27 (90%)SG = 3
F:M = 20:20Mean hospital stay = 4 d
Kral et al[77]Mean age = 40 yrAll intraoperativelyNABPD = 14222 (one late
n = 14Mean BMI = 54 kg/m2hepatic failure)
F:M = 10:4
Woodford et al[75]Mean age = 52.5 yrAll intraoperativelyA or BAGB = 14200
n = 14Mean BMI = 38.9 kg/m2
F:M = 10:4