Copyright ©The Author(s) 2015.
World J Hepatol. Sep 8, 2015; 7(19): 2202-2208
Published online Sep 8, 2015. doi: 10.4254/wjh.v7.i19.2202
Table 1 Summary of mechanisms of dendritic cell impairment
MechanismEffect on immune systemRef.
STAT3 phosphorylation and activation of PI3K pathwayReduced Th1 cell developmentTacke et al[38]
Interference with TRIF and IPS-1 signaling pathwayExhaustive function of CD8+ T-cellsRodrigue-Gervais et al[40]
Down modulation of costimulatory moleculesDC dysfunctionBain et al[32], Rana et al[54]
Upregulation of inhibitory receptorsImpaired DC function and exhaustion of T cell functionsFreeman et al[42]
Upregulation of IDOImmune toleranceSchulz et al[45]
Increased expression of SOCSNegative regulators of JAK/STAT signalling,Kim et al[52]
differentiation of DCs to tolerogenic cellLi et al[53]