Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy

doi:10.4254/wjh.v7.i15.1964

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jul 28, 2015; 7(15): 1964-1970
Published online Jul 28, 2015. doi: 10.4254/wjh.v7.i15.1964

Table 1 Molecular targets and potential therapeutic agents for hepatocellular carcinoma

Molecular targets	Therapeutic agents	Phase study	Mechanism of action
VEGF/VEGFR	Bebacizumab	II	Anti-angiogenic
	Vatalanib (PTK787)	I-II
	Cediranib (AZD2171)
	Brivanib
	Sunitinib	II-III
	Linifanib (ABT869)
	Ramucirumab
EGFR/ErbB1/Her1	Cetuximab		EGFR inhibitor
EGFR/ErbB1/Her1	Erlotinib	III
EGFR/ErbB1/Her1	Gefitinib	I-II
EGFR/ErbB1/Her1 and ErbB2/Her2/Neu	Lapatinib
IGF/IGFR	OSI-906
	IMC-A12
	AVE1642
	BIIB922
Ras/Raf/MEK/ERK	Sorafenib	III	Multi-kinase inhibitor
PI3K/Akt/mTOR	AZD8055		mTOR inhibitor
	Everolimus	III
	Sirolimus	I-II
	Temsirolimus
Wnt-β-catenin	PFK118-310
	PFK115-584
	CGP049090
MET	Tivanitib	II	HGF/c-MET inhibitor
HSP-90	STA-9090	I-II	HSP-90 inhibitor

VEGFR: Vascular endothelial growth factor receptor; EGFR: Endothelial growth factor receptor; IGF: Insulin-like growth factor; mTOR: Mammalian target of rapamycin; MET: MNNG HOS transforming gene; HGF: Hepatocyte growth factor; HSP: Heat shock protein; STA-9090: Ganetespib, Hsp90 inhibitor.

Citation: Chen C, Wang G. Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy. World J Hepatol 2015; 7(15): 1964-1970
URL: https://www.wjgnet.com/1948-5182/full/v7/i15/1964.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i15.1964