Review
Copyright ©The Author(s) 2015.
World J Hepatol. Jun 18, 2015; 7(11): 1460-1483
Published online Jun 18, 2015. doi: 10.4254/wjh.v7.i11.1460
Table 1 Genes frequently mutated in hepatocellular carcinoma
GenePathways/gene functions involvedRef.
p53Genome integrity and cell cycleClearly et al[7]
CTNNB1Wnt/β-catenin signalingKan et al[9]
ARID1AChromatin remodelingFujimoto et al[8]
mTORPI3K/AKT/mTORRiechle et al[20]
NFE2L2Oxidative/ER stressGuichard et al[16]
TERT promoterTelomere stabilityNault et al[183]
Table 2 Liver imaging reporting and data system categories
LI-RADS categorySignificance
1Definitely benign
2Probably benign
3Indeterminate
4Probably HCC
5Definitely HCC