Living-donor vs deceased-donor liver transplantation for patients with hepatocellular carcinoma

Table 1 Studies comparing living - donor liver transplantation and deceased - donor liver transplantation for hepatocellular carcinoma

Ref.	Country	Year	Study period	Type of LT	Case number	Recurrence - free survival			P	% Recur-rence rate	P	Criteria used	% Outside Milan	Differencein tumorcharact-eristics	Median follow-up period (mo)
						1-yr	3-yr	5-yr
Impaired results in LDLT
Park et al[10]	South Korea	2014	1999-2010	LDLT	166	89		81	0.045	19	0.045	UCSF	NA	none	35
				DDLT	50	96		94		6
Vakili et al[13]	United States	2009	1999-2007	LDLT	28					29	0.05	UNOS	25	none	41
				DDLT	65					12
Kulik et al[12]	United States	2012	1998-2010	LDLT	100	80	66	56	0.05	38	0.0004	UNOS	59	More aggressive in LDLT	60
	Multi-center			DDLT	97	90	81	73		11			30
Lo et al[14]	Hong Kong	2007	1995-2004	LDLT	43	93	71	71	0.029	29	0.029	UCSF	26	More aggressive in LDLT	33
				DDLT	17	100	100	100		0			29
Comparable results
Sandhu et al[15]	Canada	2013	1996-2009	LDLT	58	88	75	70	NS	17	NS	Toronto criteria	28	none	38
				DDLT	287	86	75	70		15			32		31
Bhangui et al[16]	France	2011	2000-2009	LDLT	36	100	89	88	NS	13	NS	UCSF	27	none	58
				DDLT	120	93	89	86		13			21		50
Li et al[36]	China	2010	2005-2009	LDLT	38	71	42		NS	50	NS	UCSF	79	none	25
				DDLT	101	76	41			55			68
Di Sandro et al[35]	Italy	2009	2000-2007	LDLT	25		96	96	NS	4	NS	Milan	20	none	NA
				DDLT	154		91	89		11			31
Sotiropoulos et al[20]	Germany	2007	1998-2006	LDLT	45	88	75		NS	12	NS	UCSF	44	none	NA
				DDLT	55		81			14
Hwang et al[8]	South Korea	2005	1992-2002	LDLT	237	83	80		NS	18	NS		27	none	26
	Multi-center			DDLT	75	88	82			16			29		45
Gondolesi et al[17]	United States	2004	1988-2002	LDLT	36	82	74		NS	19	NS	UNOS	53	none	15
				DDLT	165	90	83			19

DDLT: Deceased - donor liver transplantation; HCC: Hepatocellular carcinoma; LDLT: Living - donor liver transplantation; LT: Liver transplantation; UCSF: University of California, San Francisco; UNOS: United Network for Organ Sharing; NA: Not applicable; NS: Not significant.

Table 2 Graft characteristics and hepatocellular carcinoma recurrence

	Patients with recurrence(n = 11)	Patients without recurrence(n = 114)	P
Regeneration rate at 3 mo (%)	90 ± 24	93 ± 34	0.732
Graft type: right/left	4/7	36/78	0.702
Initial graft volume ratio to standard liver volume (%)	46 ± 9	47 ± 9	0.842