Brief Article
Copyright ©2013 Baishideng Publishing Group Co.
World J Hepatol. Sep 27, 2013; 5(9): 505-512
Published online Sep 27, 2013. doi: 10.4254/wjh.v5.i9.505
Table 1 Body mass index -z score, fat fraction, liver echogenicity, liver biochemical parameters and lipid profile of the studied population at baseline and at the end of intervention, values are mean (SD)+ and median or number of observation (%)
VariableBaseline (n = 46)End of intervention (n = 46)1P value
BMI Z score2.3 (0.4); 2.11.90 (0.6); 1.9< 0.001
Fat fraction (%)7.8 (13.3)0.01 (8.3)< 0.001
FF ≥ 5%21 (45.7)5 (10.9)< 0.001
FF ≥ 9%16 (34.8)4 (8.7)< 0.001
Liver echogenicity (%)
025 (54.3)36 (78.3)< 0.0001
114 (30.4)9 (19.6)
26 (13.0)1 (2.2)
31 (2.2)0 (0.0)
ALT (UI/L)34.8 (12.0); 29.023.8 (8.70); 22.50< 0.001
AST (UI/L)30.7 (10.1); 29.025.9 (7.50); 26.00< 0.001
γGT (UI/L)15.7 (5.2); 15.013.1 (3.80); 12.00< 0.001
Total cholesterol (mmol/L)4.39 (0.70); 4.484.30 (0.76); 4.230.211
HDL cholesterol (mmol/L)1.22 (0.24); 1.231.21 (0.22); 1.240.916
LDL cholesterol (mmol/L)2.64 (0.59); 2.602.60 (0.67); 2.560.306
Triglycerides (mmol/L)1.31 (0.62); 1.200.99 (0.46); 0.94< 0.001
Apo A1 (g/L)1.24 (0.21); 1.211.28 (0.21); 1.260.122
Apo B (g/L)0.73 (0.17); 0.700.66 (0.15); 0.670.022
Table 2 Spearman correlation coefficent (P value) of fat fraction and liver echogenicity with liver function parameters
ASTALTγGT
Baseline
Fat fraction0.634 (< 0.0001)0.456 (< 0.001)0.469 (< 0.0001)
Liver echogenicity0.282 (0.0530)0.437 (< 0.001)0.232 (0.0750)
End of treatment
Fat fraction0.351 (0.0170)0.297 (0.056)0.279 (0.0630)
Liver echogenicity0.260 (0.1030)0.242 (0.070)0.116 (0.2540)
Change (end of treatment-baseline)
Fat fraction0.326 (0.0270)0.331 (0.024)0.271 (0.0720)
Liver echogenicity0.225 (0.0820)0.260 (0.063)0.204 (0.1900)
Table 3 Liver biochemical parameters and lipid profile of the studied population at baseline and at the end of intervention in relation to liver FF, dichotomized at 9%, alues are mean (SD)+ and median
Baseline (n = 46)
1P valueEnd of intervention (n = 46)
1P value
FF < 9% (n = 30)FF9% (n = 16)FF < 9% (n = 42)FF9% (n = 4)
2AST (UI/L)26.70 (5.9); 26.0038.20 (12.3); 400.00129.10 (8.6); 28.5034.70 (6.4); 33.000.015
2ALT (UI/L)26.50 (7.7); 25.0050.50 (28.3); 48.500.00130.50 (13.6); 29.0040.70 (16.1); 40.500.015
2γGT (UI/L)14.40 (5.0); 13.0018.20 (4.8); 17.500.01815.40 (5.3); 14.5016.00 (3.7); 15.500.092
Triglycerides (mmol/L)1.14 (0.44); 1.101.62 (0.80); 1.380.0130.96 (0.44); 0.891.36 (0.45); 1.250.090
Total cholesterol (mmol/L)4.34 (0.69); 4.354.48 (0.74); 4.540.5394.22 (0.73); 4.185.06 (0.62); 4.980.034
HDL cholesterol (mmol/L)1.23 (0.21); 1.241.20 (0.29); 1.170.7161.21 (0.20); 1.241.23 (0.36); 1.210.950
LDL cholesterol (mmol/L)2.58 (0.61); 2.582.76 (0.56); 2.750.3482.54 (0.63); 2.533.21 (0.75); 3.030.086
Apo A (g/L)1.21 (0.01); 1.231.29 (0.24); 1.200.2591.29 (0.21); 1.271.12 (0.13); 1.120.199
Apo B (g/L)0.71 (0.18); 0.680.77 (0.15); 0. 700.2610.65 (0.14); 0.020.85 (0.13); 0. 860.064