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©2012 Baishideng Publishing Group Co.
World J Hepatol. Mar 27, 2012; 4(3): 105-109
Published online Mar 27, 2012. doi: 10.4254/wjh.v4.i3.105
Published online Mar 27, 2012. doi: 10.4254/wjh.v4.i3.105
Table 1 Comparison of IL-18 gene promoter polymorphism between patients with chronic hepatitis B and controls
| Position | Polymorphism | Control | Patient | X2 | P value | OR (95% CI) |
| n = 301 (%) | n = 501 (%) | |||||
| rs1946518 | AA | 60 (0.199) | 141 (0.281) | 6.742 | 0.009 | 1.573 (1.116-2.218) |
| AC | 156 (0.518) | 239 (0.477) | 1.279 | 0.258 | 0.848 (0.637-1.129) | |
| CC | 85 (0.269) | 121 (0.242) | 1.437 | 0.200 | 0.809 (0.585-1.119) | |
| A | 276 (0.279) | 521 (0.619) | 10.84 | 0.017 | 1.279 (1.045-1.567) | |
| C | 326 (0.622) | 481 (0.381) | ||||
| rs574424 | CC | 127 (0.422) | 198 (0.395) | 0.557 | 0.456 | 0.895 (0.670-1.197) |
| GC | 134 (0.445) | 232 (0.463) | 0.243 | 0.622 | 1.075 (0.806-1.433) | |
| GG | 40 (0.133) | 71 (0.142) | 0.123 | 0.751 | 1.070 (0.705-1.623) | |
| C | 388 (0.645) | 628 (0.627) | 0.512 | 0.475 | 0.926 (0.750-1.149) | |
| G | 214 (0.355) | 374 (0.373) |
Table 2 Haplotype frequencies of two interleukin-18 bi-allelic polymorphisms in chronic hepatitis B and healthy controls
| Haplotypes | rs1946518 | rs574424 | Controls(%) | Patients(%) | X2 | P value |
| I | A | C | 62 (10.3) | 147 (14.7) | 2.02 | 0.155 |
| II | A | G | 214 (35.5) | 374 (37.3) | 0.511 | 0.475 |
| III | C | C | 326 (54.2) | 481 (48.0) | 2.623 | 0.101 |
- Citation: Li N, Gao YF, Zhang TC, Chen P, Li X, Su F. Relationship between interleukin 18 polymorphisms and susceptibility to chronic hepatitis B virus infection. World J Hepatol 2012; 4(3): 105-109
- URL: https://www.wjgnet.com/1948-5182/full/v4/i3/105.htm
- DOI: https://dx.doi.org/10.4254/wjh.v4.i3.105