Hepatitis B virus markers in hepatitis B surface antigen negative patients with pancreatic cancer: Two case reports

doi:10.4254/wjh.v14.i7.1512

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Jul 27, 2022 (publication date) through Apr 25, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Hepatol. Jul 27, 2022; 14(7): 1512-1519
Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1512

Table 1 Results of special examination of blood and pancreatic tissue samples

	Subject 1	Subject 2
HBsAg (blood)	Negative	Negative
Anti-HBc (blood)	Positive	Positive
Anti-HBs (blood)	Positive	Negative
HBV DNA, IU/mL (blood)	Not detected	Not detected
HBV DNA, IU/mL (pancreatic tissue)	364	1183
pgRNA HBV, IU/mL (pancreatic tissue)	520	Not detected
cccDNA, copies/cell x 10^-6(pancreatic tissue)	314	Not detected
HBxAg (pancreatic tissue)	Positive	Positive
HBx - positive cells¹, % (pancreatic tissue)	3.4	3.7

¹Median values by several fields of vision. HBsAg: Hepatitis B surface antigen; Anti-HBc: Antibody to hepatitis B core antigen; Anti-HBs: Antibody to hepatitis B surface antigen; pgRNA: Pregenomic RNA; cccDNA: Covalently closed circular DNA; HBxAg: Hepatitis B X antigen; HBV: Hepatitis B virus.

Citation: Batskikh S, Morozov S, Kostyushev D. Hepatitis B virus markers in hepatitis B surface antigen negative patients with pancreatic cancer: Two case reports . World J Hepatol 2022; 14(7): 1512-1519
URL: https://www.wjgnet.com/1948-5182/full/v14/i7/1512.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i7.1512