Pathogenesis of autoimmune hepatitis

Table 1 Susceptibility genes of autoimmune hepatitis

Type of AIH	Susceptibility genes or alleles (protective alleles are in bold)	Country	Ref.
AIH I	DRB1*03:01, DRB1*04:01, DRB1*15:01	European, North American	Higuchi et al[1], 2021
			Higuchi et al[2], 2019
	DRB1*04:01, DRB1*04:05, DRB1*13:02, DRB1*15:01, DRB1*0802, DRB1*0803	Japanese	Higuchi et al[1], 2021
			Higuchi et al[2], 2019
	DRB1*0404, DRB1*0405, DRB1*1301, DRB1*1302	Latin American	Duarte-Rey et al[4], 2009
	DQB1*02, DQB1*0603, DQB1*0301, DR5, DQ3, DQ2	Latin American	Duarte-Rey et al[4], 2009
	Fas-670a/g	New Zealand, China, United States, Japan	Yan et al[5], 2020
	GATA-2	European, Caucasian ancestry	Webb et al[7], 2016
	TBX21-1993C	China	Sun et al[8], 2017
	STAT4 (rs7582694-c, rs7574865-t), Ptpn22-rs2476601	China, Japan	Li et al[9], 2017
	CTLA4	European, Japanese	Chaouali et al[10], 2018
	SH2B3, VDR, FAS-1377g/a, TNFAIP3	Japanese	Ngu et al[3], 2017
			Yan et al[5], 2020
			Kempinska-Podhorodecka et al[6], 2020
			McReynolds et al[11], 2018
	SH2B3, CARD10	Netherlands	Motawi et al[13], 2019
	MIF-173gc	United States, Japan	Alsayed et al[14], 2020
AIH II	DRB1*0701, DRB1*0201	European	Ngu et al[3], 2017
			Duarte-Rey et al[4], 2009
	DRB1*0301	British and Brazilian	Ngu et al[3], 2017
	DQB1*0201	Latin American	Duarte-Rey et al[4], 2009

AIH: Autoimmune hepatitis.