Case Report
Copyright ©The Author(s) 2020.
World J Hepatol. Dec 27, 2020; 12(12): 1341-1348
Published online Dec 27, 2020. doi: 10.4254/wjh.v12.i12.1341
Table 1 Baseline demographics prior to sofosbuvir/velpatasvir/voxilaprevir therapy
Patient No.
Age/Sex
Race
HCC
Decompensated cirrhosis
HCV RNA (IU/L)
Downstaged within Milan criteria
Within Milan criteria on explant
151 MAAYesNo27461835YesYes
268 MOYesNo944857YesNo
366 MAAYesYes894000NoYes
470 MAAYesNo14700000NoYes
548 MAAYesYes3150000NoYes
668 FAAYesNo902415811
Table 2 Patients who completed sofosbuvir/velpatasvir/voxilaprevir after liver transplant
Patient No.
GT
Pre-transplant child-pugh
Previous therapies
LOT (wk)
Time to start (d)
SVR 12
ACR
11a/4BL/S2431YesNo
21/4BIFN/RBV106YesNo
SOF/RBV
L/S24
31bBL/S 12132YesNo
41bAL/S 12256YesNo
51/4BS/S 12120YesNo
L/S24
61a1L/S127853YesNo
E/G216
Table 3 Immunosuppressive medication changes while receiving sofosbuvir/velpatasvir/voxilaprevir

1
2
3
4
5
6
Baseline regimenTacrolimus 3/4Tacrolimus 2/1Tacrolimus 2/2Tacrolimus 4/4Tacrolimus 5/5Tacrolimus 3/3
MMF 1000 mg BIDMMF 500 mg BIDMMF 500 mg BIDMMF 360 mg BID
Prednisone 20 mg QDPrednisone 10 mg QD
Week 1TL: 14.5 ng/mL ↓
Tacrolimus 3/3
MMF 1000 mg BID
Prednisone 15 mg QD
Week 2TL: 12.9 ng/mL ↓
Tacrolimus 3/2
MMF 1000 mg BID
Prednisone 15 mg QD
Week 3TL: 8.3 ng/mL ↓TL: 13.5 ng/mL↓TL: 8.6 ng/mL ↓
Tacrolimus 3/2Tacrolimus 1/1Tacrolimus 4/3
MMF 1000 mg BIDMMF 500 mg BID
Prednisone 10 mg QD
Week 4TL: 8.9 ng/mL↓
Tacrolimus 5/4
Week 5TL: 8.8 ng/mL↓TL: 10.9 ng/Ml ↓
Tacrolimus 3/2Tacrolimus 3/3
MMF 1000 mg BID
Prednisone 5 mg QD
Week 6TL: 11.5 ng/mL↓TL: 8.7 ng/mL
Tacrolimus 2/2Tacrolimus 4/4
MMF 1000 mg BID
Prednisone 5 mg QD
Week 7
Week 8
Week 9MMF discontinued2TL: 2.7 ng/mL↓
Tacrolimus 3/2
MMF 500 mg BID
Week 10TL: 10.7 ng/mL ↓
Tacrolimus 1/0.5
Week 11TL: 14.1 ng/mL ↓
Tacrolimus 1/1
MMF discontinued1
Prednisone 5mg QD
Week 12Tacrolimus 1/1Tacrolimus 1/0.5TL: 4.6 ng/mL ↓Tacrolimus 3/23Tacrolimus 4/4TL: 2.2 ng/mL ↓
Prednisone 5 mg QDTacrolimus 3/3Tacrolimus 3/4
MMF 500 mg BIDMMF 360 mg BID
Prednisone 10 mg QD