Wilson disease developing osteoarthritic pain in severe acute liver failure: A case report

Table 1 Clinical data during hospitalization and follow-up

	Day 0	Day 1	Day 3	Day 5	Day 7	Day 14	Day 21	Day 31	Day 42	Day 61	Day 98	Day 118	Day 180	Day 287	Day 371	Day 441
WBC (×103/μL)	9.6	7.5	6.6	4.7	5	3.5	3.9	4.1	4.1	5.6	5.9	3.9	5.3	4.9	5.8	5.7
Hb (g/dL)	9.5	9.8	10.7	10.9	10.8	10.7	9.6	9.3	8.9	8.3	8.9	8.9	9.4	9.8	10.5	11.6
Plt (103/μL)	126	144	145	130	124	43	46	51	58	69	91	80	132	187	166	160
PT (%)	18	18	23	24	22	21	19	20	22	24	31	31	43	57	60	79
PT-INR	3.1	3	2.5	2.3	2.7	2.6	2.8	2.7	2.6	2.5	2.1	2.1	1.7	1.4	1.3	1.1
APTT (%)	27	26	30	29	24	28	22	23	22	24	35	38	50	66	78	78
ATIII (%)	NA	20	22	45	46	51	53	33	25	26	35	32	64	90	115	136
Factor V(%)	NA	NA	NA	NA	13	16	15	19	15	25	33	27	46	81	84	80
BUN (mg/dL)	9.9	7	8.3	7.1	7.7	9.8	8.4	9.8	9.2	8.6	8	8.1	8.7	10.7	8.5	9.6
Cr (mg/dL)	0.49	0.5	0.52	0.47	0.48	0.44	0.43	0.38	0.34	0.35	0.29	0.32	0.33	0.29	0.31	0.36
AST (IU/L)	156	79	53	48	47	76	51	60	55	55	69	75	64	43	38	31
ALT (IU/L)	67	26	30	29	33	69	49	50	42	39	54	68	53	46	45	39
LDH (IU/L)	450	386	290	272	258	247	222	219	217	218	256	286	263	196	179	188
T-Bil (mg/dL)	4.9	2.6	2	1.7	1.4	1.8	2	2.4	3.2	2.9	1.3	1.1	0.5	0.4	0.4	0.3
D-Bil (mg/dL)	1.5	0.8	0.5	0.4	0.2	0.3	0.4	0.6	0.9	0.8	0.2	0.1	0.1	0.1	0.1	0.1
TP (g/dL)	4.8	5.8	6.2	6.3	6.1	6.4	6.4	6.7	7	6.9	6.5	6.1	6.8	7.6	7.3	7.6
ALB (g/dL)	1.4	1.6	2.4	2.5	2.4	2.7	2.9	3.1	3.1	3.2	2.8	2.6	3.3	4.3	4.3	4.7
1PELD score	26	22	14	12	14	14	15	15	16	14	8	8	2	-4	-5	-9
NWIS	12	9	7	5	7	6	6	6	6	6	5	5	4	2	2	0
The Devarbhavi’s score	8.11	5.65	2.14	1.82	1.50	1.93	2.14	2.57	3.42	3.10	1.39	1.18	0.54	0.43	0.43	0.32
Hepatic encephalopathy	I	I	0	0	0	0	0	0	0	0	0	0	0	0	0	0

¹PELD score: All the scores were described in the PELD score, though the patient’s age was 12 years at Day 287; Day 371; and Day 441. WBC: White blood cell count; Hb: Hemoglobin; Plt: Platelets; PT: Prothrombin time; PT-INR: Prothrombin time international normalized ratio; APTT: Activated partial thromboplastin time; AT III: Antithrombin III; BUN: Blood urea nitrogen; Cre: Creatinine; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; LDH: Lactate dehydrogenase; T-Bil: Total bilirubin; D-Bil: Direct bilirubin; TP: Total protein; Alb: Albumin; NA: Not available.