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©2009 Baishideng.
World J Hepatol. Oct 31, 2009; 1(1): 28-34
Published online Oct 31, 2009. doi: 10.4254/wjh.v1.i1.28
Published online Oct 31, 2009. doi: 10.4254/wjh.v1.i1.28
Table 1 Liver proteinases implicated in tumor progression and metastasis
| Name | Type | Inhibitors | Localization | Physiological function |
| Cathepsin B | Cysteine | Cystatins (A-E) | Lysosomal | General protein turnover |
| Cathepsin D | Aspartic | - | Lysosomal | General protein turnover |
| Cathepsin L | Cysteine | Cystatins (A-F) | Lysosomal | General protein turnover |
| MMP-2 | Metallo | TIMPs (1-4) | Extracellular | Matrix remodelling |
| MMP-3 | Metallo | TIMPs (1-4) | Extracellular | Matrix remodelling |
| MMP-7 | Metallo | TIMPs (1-4) | Extracellular | Matrix remodelling |
| MMP-9 | Metallo | TIMPs (1-4) | Extracellular | Matrix remodelling |
| uPA | Serine | PAI-1, PAI-2 | Extracellular | Fibrinolysis |
| tPA | Serine | PAI-1 | Extracellular | Fibrinolysis |
- Citation: Puxbaum V, Mach L. Proteinases and their inhibitors in liver cancer. World J Hepatol 2009; 1(1): 28-34
- URL: https://www.wjgnet.com/1948-5182/full/v1/i1/28.htm
- DOI: https://dx.doi.org/10.4254/wjh.v1.i1.28