Hepatitis C virus genetic variability and evolution

Figure 2 Evolutionary tree of the seven genotypes and all known subtypes of hepatitis C virus. The tree was constructed using the maximum likelihood method using GTR + I + G (general time-reversible substitution model considering invariable sites and gamma distribution) as the nucleotide substitution model that best fitted the data using a 307-nucleotide sequence from the NS5B-coding region. Sequences used for the construction of this phylogenetic tree were extracted from Yusim et al[155].