Copyright ©The Author(s) 2015.
World J Hepatol. Nov 8, 2015; 7(25): 2571-2577
Published online Nov 8, 2015. doi: 10.4254/wjh.v7.i25.2571
Table 2 Principle differences in the definition and diagnostic criteria of acute-on-chronic liver failure between Asia-Pacific and West
APASL definitionEASL-CLIF definition
Total bilirubin5 mg/dL or more12 mg/dL or more
INR1.5 or more2.5 or more
Hepatic encephalopathyAny gradeOnly grade III and IV
AscitesMay be presentNot included
Duration between insult and ACLF4 wkNot defined
Acute event - sepsisNoYes
Acute event - variceal bleedingNo unless producing jaundice and coagulopathy defining ACLFYes
Extra-hepatic organ involvementNoYes
What is chronic diseaseChronic liver disease with/without only compensated cirrhosisOnly cirrhosis, including those with prior decompensation