Ciclosporin does not attenuate intracranial hypertension in rats with acute hyperammonaemia

Figure 2 Brain water content. A: Bar plot of mean cortical water content in the experimental groups after 4 h of ammonia infusion. Error bars represent standard error of the mean. A significant effect of ammonia infusion on cortical water content was found (two-way analysis of variance, F = 7.8, P < 0.05). We found no effect of Cs; B: Bar plot of mean cerebellar water content in the experimental groups after 4 h of ammonia infusion. Error bars represent standard error of the mean. A highly significant effect of ammonia on increased cerebellar water content was found (two-way analysis of variance, F = 16.2, P < 0.001). We found no effect of Cs. PCA: Portacaval anastomosis; Cs: Ciclosporin.