Hepatitis C virus-related hepatocellular carcinoma: An insight into molecular mechanisms and therapeutic strategies

Figure 1 Hepatitis C virus genome including 5’ and 3’ noncoding regions, and the long open reading frame encoding for polyprotein precursor of 3010 amino acids. This polyprotein precursor can be cleaved functionally by co- and post-translationally processes mediated by cellular and viral proteases into ten different products, including structural and non-structural proteins. The structural proteins core (C), envelop 1 (E1) and E2 are located in the N-terminal third, whereas, the non-structural/replicative proteins (NS2, NS3, NS4A, NS4B, NS5A, NS5B) are located in the remainder of the polyprotein. Putative functions of the cleavage products are shown.