Mortality and health care burden of Budd Chiari syndrome in the United States: A nationwide analysis (1998-2017)

Table 2 Trends in outcomes of interest

	1998-2017 (unweighted: 8435, weighted: 41119)	1998 (unweighted: 262, weighted: 1367)	2017 (unweighted: 680, weighted: 3400)	APC (95%CI)	P value for APC
Procedures
Number of procedures	2.64 (0.03)	3.09 (0.20)	2.42 (0.13)	-0.51% (-1.09%, 0.06%)	0.082
Paracentesis	18.41 (0.42)	28.56 (2.82)	16.47 (1.42)	-1.67% (-2.53%, -0.81%)	0.000
Upper endoscopy	10.94 (0.34)	13.08 (2.06)	11.91 (1.24)	-0.17% (-1.31%, 0.97%)	0.766
Liver biopsy	6.24 (0.26)	10.35 (1.9)	5.15 (0.85)	-4.01% (-5.42%, -2.58%)	< 0.0001
Portosystemic shunt/TIPS	3.63 (0.2)	6.12 (1.54)	2.94 (0.65)	-4.95% (-6.78%, -3.09%)	< 0.0001
Liver transplantation	1.9 (0.15)	1.29 (0.75)	2.06 (0.54)	-2.68% (-5.26%, -0.02%)	0.048
Disposition of patient
1: Discharged to home or selfcare	58.8(0.54)	50.71 (3.12)	55.96 (1.91)	-0.28% (-0.77%, 0.21%)	0.262
6: Home health care	13.49 (0.37)	12.04 (2.04)	17.23 (1.45)	3.31% (2.20%, 4.43%)	< 0.0001
5: Transfer: other type of facility	11.12 (0.34)	10.21 (1.89)	12.08 (1.25)	1.87% (0.70%, 3.06%)	0.002
20: Died in hospital	8.74 (0.31)	18.17 (2.44)	7.66 (1.02)	-4.31% (-5.50%, -3.10%)	< 0.0001
2: Transfer: short-term hospital	6.8 (0.28)	8.25 (1.71)	5.6 (0.88)	-1.26% (-2.66%, 0.17%)	0.084
7: Against medical advice	1 (0.11)	0.61 (0.43)	1.47 (0.46)	2.94% (-1.02%, 7.07%)	0.148
Outcomes
Number of deaths	737 (Unweighted); 3591 (Weighted)	46 (Unweighted); 249 (Weighted)	52 (Unweighted); 260 (Weighted)
Mortality rate per 1000000 United States populations		0.9	0.8	-0.29% (-0.86%, 0.27%)	0.309
Mortality rate per 1000000 inpatients		8.87	8.55	0.34% (-0.23%, 0.92%)	0.243
Mortality rate among BCS inpatients	0.09	0.18	0.08	-4.41% (-4.95%, -3.88%)	< 0.0001
Length of stay (d)	8.84 (0.13)	12.73 (1.01)	7.64 (0.36)	-2.04% (-2.67%, -1.41%)	< 0.0001
Average total charges in 2017 dollars	94440.04 (1996.06)	95515.01 (9483.24)	103850.98 (8183.79)	1.15% (0.35%, 1.96%)	0.005

All data are presented as percentage (SE) for categorical variables and mean (SE) for continuous variables. Annual percentage change (APC) > 0 means increasing, < 0 means decreasing. P value for APC measures if APC is significantly different from zero. P value ≤ 0.05 means the change is significant. BCS: Budd Chiari syndrome; APC: Annual percentage change.