Bile acid indices as biomarkers for liver diseases I: Diagnostic markers

Table 7 Univariate logistic regression analysis of bile acids concentrations and indices¹

BA (µmol/L) or BA indices	B value (regression coefficient)	P value	Exp(B)-odds ratio
			1-unit change	10% change	20% change
Total BA	0.080	0.000	1.08	1.08	1.16
Total CDCA	0.226	0.000	1.25	1.06	1.12
Total CA	1.181	0.000	3.26	1.05	1.11
% DCA	-0.080	0.000	0.92	0.78	0.61
% HDCA	-1.898	0.069	0.15	0.99	0.97
% MDCA	-0.174	0.162	0.84	0.99	0.98
Total G-amidated	0.084	0.000	1.09	1.07	1.14
Total unsulfated	0.784	0.000	2.19	1.08	1.16
Total sulfated	0.080	0.000	1.08	1.07	1.14
Total di-OH	0.094	0.000	1.10	1.07	1.15
Total tri-OH	0.731	0.000	2.08	1.06	1.13
Total non-12α-OH	0.146	0.000	1.16	1.09	1.18
12α-OH/non12α-OH	-2.349	0.000	0.10	0.86	0.74
% 12α-OH	-0.079	0.000	0.92	0.75	0.56
% non-12α-OH	0.079	0.000	1.08	1.65	2.72
Total primary	0.190	0.000	1.21	1.07	1.14
Primary/secondary	0.834	0.000	2.30	1.06	1.12
% Primary	0.033	0.000	1.03	1.13	1.27
% Secondary	-0.033	0.000	0.97	0.81	0.66

¹Bile acids with receiver operating characteristic (ROC)-areas under the ROC curve > 0.7 were included in this table.

BA: Bile acids; G: Glycine; CDCA: Chenodeoxycholic acid; CA: Cholic acid; DCA: Deoxycholic acid; HDCA: Hyodeoxycholic acid; MDCA: Murideoxycholic acid.