Bile acid indices as biomarkers for liver diseases I: Diagnostic markers

Table 6 Representative bile acids concentrations and indices in compensated vs decompensated patients

BA (µmol/L) or BA indices	Compensated		Decompensated		Decompensated vs compensated
	mean	SE	mean	SE	Ratio	P value
Total BA	66.6	10.8	86.9	14.9	1.31	0.160
Total LCA	3.73	0.54	4.26	0.70	1.14	0.547
Total UDCA	27.0	6.49	21.0	9.82	0.78	0.687
Total CDCA	20.4	3.42	45.0	6.28	2.20	0.001
Total DCA	6.85	1.76	4.93	0.73	0.72	0.394
Total HDCA	0.01	0.00	0.02	0.01	1.61	0.430
Total MDCA	0.06	0.01	0.05	0.01	0.86	0.619
Total CA	2.62	0.40	6.28	1.51	2.39	0.024
Total MCA	4.48	0.93	4.07	0.83	0.91	0.864
Total HCA	0.20	0.04	0.64	0.14	3.23	0.002
% LCA	9.00	0.64	6.61	0.64	0.73	0.020
% UDCA	24.9	1.97	12.0	1.32	0.48	0.007
% CDCA	33.2	1.62	54.74	2.05	1.65	0.000
% DCA	14.3	0.98	9.17	1.00	0.64	0.000
% HDCA	0.02	0.01	0.03	0.01	1.42	0.532
% MDCA	0.34	0.14	0.11	0.01	0.33	0.264
% CA	6.07	0.54	7.58	0.48	1.25	0.262
% MCA	7.26	0.72	7.21	0.82	0.99	0.542
% HCA	0.35	0.05	0.74	0.08	2.09	0.005
Total unamidated	4.35	0.69	3.88	1.04	0.89	0.876
Total G-amidated	56.2	9.81	70.5	12.5	1.25	0.240
Total T-amidated	5.97	0.79	12.6	2.58	2.11	0.010
% Amidation	87.9	1.15	93.6	0.75	1.06	0.003
% G-amidation	76.5	1.30	78.8	1.23	1.03	0.161
% T-amidation	11.5	0.93	14.8	1.02	1.29	0.161
Total unsulfated	7.84	1.19	9.53	1.85	1.22	0.310
Total sulfated	58.7	9.97	77.4	13.4	1.32	0.156
% Sulfation	82.7	1.12	85.2	0.99	1.03	0.054
Total mono-OH	3.73	0.54	4.26	0.70	1.14	0.547
Total di-OH	54.4	9.55	70.9	13.1	1.31	0.174
Total tri-OH	7.30	1.25	11.0	1.96	1.51	0.085
% Mono-OH	9.00	0.64	6.61	0.64	0.73	0.020
% Di-OH	72.7	1.14	76.0	1.31	1.05	0.016
% Tri-OH	13.7	0.92	15.5	0.95	1.13	0.674
Total 12α-OH	10.1	2.08	11.44	1.75	1.14	0.554
Total non-12α-OH	56.5	9.36	75.51	14.0	1.34	0.137
12α-OH/non12α-OH	0.33	0.02	0.24	0.02	0.71	0.002
CA/CDCA	0.21	0.02	0.17	0.01	0.79	0.043
% 12α-OH	22.0	1.07	17.3	0.99	0.79	0.001
% non-12α-OH	78.0	1.07	82.7	0.99	1.06	0.001
Total primary	27.7	4.46	56.0	7.59	2.02	0.001
Total secondary	38.8	7.43	31.0	10.3	0.80	0.874
Primary/secondary	2.27	0.44	5.98	0.69	2.64	0.001
% Primary	46.9	2.05	70.3	1.88	1.50	0.000
% Secondary	53.1	2.05	29.7	1.88	0.56	0.000

BA: Bile acids; G: Glycine; T: Taurine; CDCA: Chenodeoxycholic acid; CA: Cholic acid; LCA: Lithocholic acid; UDCA: Ursodeoxycholic acid; DCA: Deoxycholic acid; HDCA: Hyodeoxycholic acid; MDCA: Murideoxycholic acid; MCA: Muricholic acid; HCA: Hyocholic acid.