Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites

Table 4 Univariate and multivariate analysis of baseline characteristics regarding the risk of death during follow-up in all patients

Variables	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)	1.042 (1.026-1.056)	< 0.001	1.035 (1.016-1.054)	< 0.001
HCV etiology	1.99 (1.385-2.865)	< 0.001
Diabetes mellitus	1.583 (1.097-2.283)	0.010
Active alcohol intake	0.353 (0.230-0.542)	< 0.001	0.568 (0.345-0.935)	0.020
Child-Pugh score	1.170 (1.041-1.317)	0.008	1.263 (1.113-1.432)	< 0.001
MELD score	1.036 (1.007-1.066)	0.010
Previous decompensation	2.33 (1.473-3.690)	< 0.001
Previous ascites	2.50 (1.620-3.860)	< 0.001
Previous encepalophathy	2.794 (1.908-4.092)	< 0.001	2.216 (1.493-3.290)	< 0.001
Hepatocellular carcinoma	2.872 (1.097-4.817)	< 0.001	2.381 (1.411-4.018)	< 0.001
Previous β-blockers	1.727 (1.194-2.498)	0.004
Previous diuretics	1.957 (1.334-2.869)	0.001
Serum creatinine (μmol/L)	1.006 (1.004-1.008)	< 0.001	1.005 (1.002-1.007)	< 0.001
Serum urea (mmol/L)	1.026 (1.013-1.040)	< 0.001
Platelet count (× 109/L)	0.997 (0.995-1.00)	0.032
TLR4 polymorphisms	1.372 (0.770-2.445)	0.280

HCV: Hepatitis C virus; MELD: Model for end-stage liver disease.