In vivo assessment of intratumoral aspirin injection to treat hepatic tumors

Figure 1 Photomicrograph of surgical specimen from liver VX2 tumor. A: 24 h after saline injection revealing a large tumor nodule (white arrow) surrounded by normal hepatic tissue with no signs of necrosis (black arrow). (Hematoxylin-eosin, original magnification × 100); B: 24 h after 10% aspirin solution injection showing extensive necrotic areas (black arrow). (Hematoxylin-eosin, original magnification × 200); C: 7 d after saline injection demonstrating a large viable tumor nodule (white arrow) with normal adjacent hepatic parenchyma (black arrow). (Hematoxylin-eosin, original magnification × 200); D: 7 d after 10% aspirin solution injection showing normal hepatic parenchyma (black arrow) surrounded by inflammatory infiltrate and fibrosis (white arrows). (Hematoxylin-eosin, original magnification × 100).