Copyright ©2010 Baishideng.
World J Hepatol. Jan 27, 2010; 2(1): 21-31
Published online Jan 27, 2010. doi: 10.4254/wjh.v2.i1.21
Figure 1
Figure 1 99mTc radiotracers useful for heart imaging. 99mTc-Sestamibi, 99mTc-Tetrofosmin and 99mTc-Teboroxime have been approved as commercial radiopharmaceuticals for myocardial perfusion imaging.
Figure 2
Figure 2 Cationic 99mTc-nitrido complexes with fast liver clearance and excellent heart/liver ratios. Both 99mTcN-DBODC5 and 99mTcN-MPO are under clinical investigation as new myocardial perfusion imaging agents.
Figure 3
Figure 3 Crown ether-containing DTCs, bisphosphines and their cationic 99mTc-nitrido complexes.
Figure 4
Figure 4 Cationic 99mTc(I)-tricarbonyl complexes with crown ether-containing PNP bisphosphines.
Figure 5
Figure 5 Comparison of heart/liver ratios between [99mTcN(L4)(L6)]+ (99mTcN-15C5), [99mTcN(mpo)(PNP5)]+ (99mTcN-MPO), [99mTc(CO)3(15CPNP)]+ (99mTc-15C5PNP), 99mTc-Sestamibi and 99mTcN-DBODC5 in SD rats.
Figure 6
Figure 6 Planar images and organ clearance kinetics of normal dogs. A: Planar images of normal dogs administered with 99mTcN-MPO and 99mTc-Sestamibi. Both radiotracers had similar initial myocardial uptake; B: Imaging quantification in normal dogs administered with 99mTcN-MPO; C: Imaging quantification in normal dogs administered with 99mTc-Sestamibi. The liver radioactivity of 99mTcN-MPO was markedly decreased within first 60 min whereas 99mTc-Sestamibi had a slower reduction in liver radioactivity over time. A mild myocardial washout was observed in the dogs administered with 99mTcN-MPO. No significant myocardial washout was seen in dogs administered with 99mTc-Sestamibi.
Figure 7
Figure 7 SPECT images of the same dog (with acute myocardial infarction) administered with ~10 mCi of 99mTc-Sestamibi and 99mTcN-MPO at 30 and 60 min p. i. Arrows indicate the presence of perfusion defects due to myocardial infarction. For 99mTcN-MPO, the perfusion defects were clearly seen as early as 30 min post-injection due to its fast liver clearance. For 99mTc-Sestamibi, there was a significant between the perfusion defects and the liver radioactivity.
Figure 8
Figure 8 The whole-body images of representative a healthy volunteer administered with 99mTcN-MPO. A: Administered with 99mTcN-MPO (~25 mCi) at 10, 30, 60 and 240 min post-injection; B: Representative SPECT images of the heart after administration of 99mTcN-MPO (~25 mCi) at 60 min post-injection.
Figure 9
Figure 9 Planar images of the SD rats administered with ~1. 0 mCi of 99mTcN-MPO in the absence and presence of cyclosporin-A at 30 and 60 min post-injection. Pre-treatment with cyclosporin-A (14 mg/kg) results in more liver radioactivity accumulation and slower liver clearance.