Vitamin A toxicity and hepatic pathology: A comprehensive review

doi:10.4254/wjh.v17.i8.107738

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Aug 27, 2025 (publication date) through Aug 27, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Aug 27, 2025; 17(8): 107738
Published online Aug 27, 2025. doi: 10.4254/wjh.v17.i8.107738

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Figure 1 Histology. A: Hematoxylin-eosin (HE)-stained liver biopsy section, with appearance of occlusion of the sinusoids due to Ito cell hyperplasia; B: Masson’s trichrome-stained liver biopsy section with marked sinusoidal fibrosis; C: Periodic acid Schiff-stained liver biopsy section with HE, liver biopsy section with evident cytoplasmic vacuolization of Ito cells; D: Immunostaining of smooth muscle actin. Marked positivity was observed in activated Ito cells such as myofibroblasts. Magnification: 10 ×.

Citation: Pestalardo ML, Bevilacqua CS, Amante MF. Vitamin A toxicity and hepatic pathology: A comprehensive review. World J Hepatol 2025; 17(8): 107738
URL: https://www.wjgnet.com/1948-5182/full/v17/i8/107738.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i8.107738