Non-alcoholic steatohepatitis in liver transplant recipients diagnosed by serum cytokeratin 18 and transient elastography: A prospective study

Figure 1 Study design showing baseline and study visit. AUDIT-C: Alcohol Use Disorders Identification Test; BMI: Body mass index; CAP: Controlled attenuation parameter; TE: Transient elastography; CK-18: Cytokeratin 18.

Figure 2 Flow chart displaying the selection of study participants. Of 48 consecutive patients undergoing liver transplant, 3 were excluded because of invalid TE examination and 5 because they received a liver graft with steatosis involving > 10% of hepatocytes. TE: Transient elastography.

Figure 3 Hazard ratio by body mass index category in nonalcoholic fatty liver disease (log-rank: P < 0. 0001) and in nonalcoholic steatohepatitis (log-rank: P = 0.009). BMI: Body mass index; NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis.

Figure 4 Spaghetti plot of changes. A: Spaghetti plot of changes in liver stiffness measurement during study period; B: Spaghetti plot of changes in fibrosis-4 during study period; C: Spaghetti plot of changes in aspartate aminotransferase-to-Platelets Ratio Index. APRI: Aspartate aminotransferase-to-Platelets Ratio Index; FIB-4: Fibrosis-4; LSM: Liver stiffness measurement.