Lumacaftor/ivacaftor therapy is associated with reduced hepatic steatosis in cystic fibrosis patients

Figure 1 Consort diagram. Consort diagram for the study. Modulator refers to lumacaftor/ivacaftor use. CF: Cystic fibrosis, MRI: Magnetic resonance imaging; CFTR: Cystic fibrosis transmembrane conductance regulator.

Figure 2 Hepatic steatosis (proton density fat fraction) stratified by lumacaftor/ivacaftor use. Subjects receiving cystic fibrosis transmembrane conductance regulator (CFTR) modulator (lumacaftor/ivacaftor) had a median proton density fat fraction of 2.1%. Subjects not receiving CFTR modulator had a median proton density fat fraction of 4.1%. Each dot represents one subject. Horizontal lines indicate the minimum, median and maximum for each group. P = 0.002. CFTR: Cystic fibrosis transmembrane conductance regulator.