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World J Hepatol. May 27, 2012; 4(5): 169-175
Published online May 27, 2012. doi: 10.4254/wjh.v4.i5.169
Published online May 27, 2012. doi: 10.4254/wjh.v4.i5.169
Global hypomethylation in hepatocellular carcinoma and its relationship to aflatoxin B1 exposure
Yu-Jing Zhang, Hui-Chen Wu, Regina M Santella, Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 630 W 168Th St., New York, NY 10032, United States
Hulya Yazici, Department of Oncology, Oncology Institute, Istanbul University, Istanbul 34093, Turkey
Ming-Whei Yu, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei 10002, Taiwan, China
Po-Huang Lee, Department of Surgery, College of Medicine, National Taiwan University, Taipei 10002, Taiwan, China
Author contributions: Zhang YJ and Santella RM designed the research; Zhang YJ and Yazici H performed the assays; Wu HC did the statistical analysis; Yu MW and Lee PH supplied paired hepatocellular carcinoma samples and clinical data; and Zhang YJ and Santella RM wrote the paper.
Supported by A grant from the National Institute of Health, No. ES005116 and No. P30ES009089
Correspondence to: Yu-Jing Zhang, MD, Senior Research Scientist, Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, 630 W 168Th St., New York, NY 10032, United States. yz6@columbia.edu
Telephone: +1-212-3058158 Fax: +1-212-3055328
Received: November 19, 2011
Revised: February 2, 2012
Accepted: April 27, 2012
Published online: May 27, 2012
Revised: February 2, 2012
Accepted: April 27, 2012
Published online: May 27, 2012
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