Endometriosis, characterized as an inflammatory ailment, affects females during their reproductive years, leading to decreased quality of life. Despite the pivotal role of diet as a modifiable risk factor for various chronic conditions, its potential influence on endometriosis has remained inadequately explored. This research endeavor sought to scrutinize the association between dietary alternative healthy eating index, AHEI, and the likelihood of experiencing endometriosis among women in Iran.

Conducted as a hospital-centered case-control investigation, the study enlisted individuals diagnosed with endometriosis alongside healthy counterparts, confirmed by a gynecologist, between February and September 2021 in Tehran, Iran. The pattern of diet was assessed utilizing a validated Food Frequency Questionnaire (FFQ) encompassing 168 food items. Logistic regression models were employed to explore the potential connection between AHEI and the probability of endometriosis.

The analysis encompassed 105 subjects with endometriosis and 208 individuals in good health. After adjustment for total calories intake (Kcal), occupation, smoking (yes/no), age at menarche (years), menstruation duration (days), regular menstruation (yes/no), physical activity (minutes per week) and familial history of endometriosis (yes/no), it was observed that those with the high adherence to the AHEI, had about 92% lower odds of endometriosis (Odds Ratio: 0.08, 95%Confidence Intervals: 0.03, 0.24; P for trend < 0.001).

The investigation illustrated a protective effect of healthy eating index and its components on developing endometriosis.

Adiposity is a major risk factor for the development of cancers, such as breast cancer(BC) in adults. However, the role of central adiposity or general obesity as primary predictors of BC occurrence and progression is not well-established. Therefore, the current study aimed to assess the association between various adiposity indices, including a body shape index(ABSI), abdominal volume index(AVI), body roundness index(BRI), conicity index(CI), body adiposity index(BAI), reciprocal ponderal index(RPI), and waist to height0.5 ratio(WHt0.5R) as surrogates for predicting the odds of BC in adult women. This case-control study was conducted at Shohada and Imam Hossain hospitals in Tehran and included 134 newly diagnosed BC cases and 267 controls. Anthropometric variables, including weight, height, and waist circumference were measured using standard methods, and various adiposity indices were calculated accordingly. The odds ratios(ORs) with 95% confidence intervals(CIs) for BC were reported across tertiles of adiposity indices using multivariable logistic regression. Participants in the highest tertile of BRI(OR:2.07;95% CI:1.04-4.12), BAI(OR:2.06;95% CI:1.05-4.03), and WHt0.5R(OR:1.81;95% CI:1.01-3.55) had significantly higher odds of BC compared to those in the lowest tertile(P < 0.05). Additionally, each SD increase in RPI was associated with lower odds of BC(OR:0.77;95% CI:0.61-0.98,P = 0.034). However, no significant associations were observed for CI, AVI, and ABSI with the odds of BC. Our results suggest that WHtR, BRI, BAI, and WHt0.5R may be more effective predictors of BC odds among the evaluated adiposity indices.

It has been suggested that the dietary approaches to stop hypertension (DASH) diet as a plant-based dietary pattern can be useful in improvement of risk factors of metabolic syndrome (MetS). We designed a study to evaluate the effect of the DASH diet on insulin resistance and lipid accumulation product (LAP) in subjects with MetS. 60 subjects with MetS were assigned into two groups including the intervention group and the control group. The intervention group received DASH diet and the control group received a common healthy diet for 12 weeks. We measured fasting plasma glucose (FPG), triglyceride and glucose (TyG) index, metabolic score for insulin resistance (METS-IR) and LAP before and after intervention. We utilized SPSS software version 24 and an intention-to-treat method for data analysis. A total of 59 subjects completed the trial. After intervention a significant difference was observed between groups in FPG (P < 0.001), TyG index (P < 0.001) and LAP (P = 0.01). However, there was no significant difference between groups in values of METS-IR (P = 0.27). There was a significant reduction in the intervention group compared to the control group in FPG (-7.86 ± 10.08 vs. 0.97 ± 15.51; P = 0.01), TyG index (-0.20 ± 0.14 vs. 0.02 ± 0.11; P < 0.001), METS-IR (-2.50 ± 1.99 vs. -0.53 ± 2.21; P = 0.001) and LAP (-20.06 ± 12.02 vs. -5.87 ± 15.17; P < 0.001). Adherence to DASH diet can reduce some cardiovascular risk factors in subjects with MetS. Further clinical trials are required to reach a firm conclusion.

Structural neuroplasticity in the brain may contribute to the persistence of low back pain (LBP) symptoms and the disability associated with them. It is not known if structural adaptations are evident early in the lifespan in young adults with LBP. This study compared gray matter in cortical sensorimotor regions in young adults with and without persistent LBP and identified gray matter and clinical predictors of pain-related disability. Eighty-two individuals with and without a history of LBP participated. Peak and average gray matter density in cortical sensorimotor regions of interest was quantified using voxel-based morphometry. Pain-related disability, pain intensity, pain duration, and pain-related fear were also assessed. Multiple linear regression was used to determine independent predictors of pain-related disability. We document significantly greater peak gray matter density in individuals with LBP in the primary somatosensory cortex, angular gyrus, and the midcingulate cortex. Pain-related disability positively correlated with average gray matter density in the posterior cingulate cortex. The most robust predictors of disability were average gray matter in the posterior cingulate, pain intensity, and pain-related fear. We demonstrate that in young adults, persistent LBP, and pain-related disability, are linked with structural differences in regions forming part of the brain network termed the pain matrix. In contrast with studies of LBP in older adults, our findings of increased rather than decreased gray matter in young adults with LBP suggest that gray matter may increase initially in response to nociceptive pain.

The study aims to compare physical activity, sleep, body mass index (BMI), subjective health, stress, depression, impulsivity, and emotional intelligence across the Baltic countries while identifying key health determinants.

We interviewed men and women (18-64 years) in Estonia (n = 1,503) Latvia (n = 1,563) and Lithuania (n = 2,358) via an online survey.

Obesity is most common among individuals in EE, both males and females, while the highest rates of overweight are observed in EE females and LT males. Sleep duration is comparable across the different countries, with women generally sleeping longer than men (p < 0.05). Sedentary behavior is shortest among LT females and LV males, although in all countries, females tend to sit more than males (p < 0.05). Moderate physical activity (MPA) levels are similar among males, but they are highest among EE females. In contrast, vigorous physical activity (VPA) is most prevalent in LV males and females. Emotional intelligence (EI) is lowest among LV females and EE males, while females consistently exhibit higher EI than males across all countries. Lithuanians frequently rate their health as "excellent" and show the lowest levels of impulsivity. Additionally, depression and stress are lowest in EE females and LV males. Estonians are more likely to eat breakfast regularly and tend to overeat less than their counterparts in LV and LT.

Our research clearly shows that perceived health among the Baltic countries is significantly inversely related to age, perceived stress, depression, and Body Mass Index (BMI). In contrast, we found positive associations between vigorous physical activity (VPA) and emotional intelligence (EI).

Measurement reactivity, where the act of measuring a behavior changes that behavior, has been documented across various health outcomes. However, its effects on sleep remain understudied, despite the widespread use of sleep diaries in clinical and research settings. In this randomized experiment, 190 healthy young adults (aged 18-40 years; 63% female) were assigned to complete either a sleep diary (Consensus Sleep Diary) or a physical activity diary (Physical Activity Scale) for seven days. All participants completed the Pittsburgh Sleep Quality Index (PSQI) and the International Physical Activity Questionnaire (IPAQ) before and after the diary period. Daily diary completion rates were high (97.3%). Linear mixed-effects models revealed no significant main effects of time (pre vs. post) or condition (sleep vs. physical activity diary), and no significant interaction between time and condition for either PSQI or IPAQ scores. These results suggest stability in sleep quality and physical activity measures, with no evidence of measurement reactivity. An exploratory analysis comparing "good" and "poor" sleepers (based on baseline PSQI scores) found a significant effect of sleep quality group and a time × group interaction on PSQI scores. In this adequately powered short-term study of young adults, we found no evidence of measurement reactivity to daily sleep diaries. These findings suggest that in healthy individuals, completing a week of sleep diaries is unlikely to impact PSQI scores substantially. We discuss our results in terms of the direct controllability of sleep quality, which might make it less susceptible to measurement reactivity relative to other health outcomes.

Time-restricted eating (TRE) limits the time for food intake to typically 6-10 h/day without other dietary restrictions. The aim of the RESET2 (the REStricted Eating Time in the treatment of type 2 diabetes) trial is to investigate the effects on glycaemic control (HbA1c) and the feasibility of a 1-year TRE intervention in individuals with overweight/obesity and type 2 diabetes. The aim of the present paper is to describe the protocol for the RESET2 trial.

RESET2 is a randomised, controlled, parallel-group, open-label trial. One hundred and sixty individuals with type 2 diabetes (HbA1c >53 mmol/mol (>7.0%)), and Body Mass Index ≥25 kg/m2 will be randomised to standard care plus TRE, or to standard care and habitual living. Both the intervention and control group will follow standard diabetes care including regular clinical visits 3-4 times/year. The intervention is divided into two periods: (1) a 3-month TRE period with a fixed eating window with a self-selected timing to obtain data from the participants' experiences with TRE and (2) a 9-month individually adjusted TRE period. Participants in the TRE group will be instructed to reduce their eating window by a minimum of 3 h/day compared to the habitual eating window and with an eating window of 8-10 h/day. Test days will be scheduled at baseline, after 3 months and after 1 year. The primary outcome is HbA1c (evaluated 3 months and 1 year after randomisation) and secondary outcomes are body weight, fat mass, continuous glucose monitoring derived time-in-range and use of antidiabetic medicine (evaluated 1 year after randomisation). Additionally, we will conduct a process evaluation to assess whether the TRE intervention functioned as hypothesised.

While dietary factors are known to influence gallstone disease (GD), the specific role of dietary acid load (DAL) remains unclear. This study aimed to explore the relationship between DAL and GD risk using a case-control design.

The study included 189 adults with newly diagnosed GD and 342 controls. Anthropometric data were collected, and DAL was calculated using the potential renal acid load (PRAL) and net endogenous acid production (NEAP) indices. Multivariable logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI), adjusting for confounders.

Participants in the higher tertiles of both PRAL and NEAP scores showed notably elevated grain consumption and reduced intake of vegetables and fruits (P < 0.001). Conversely, an inverse relationship was observed between NEAP scores and intake of legumes, nuts, and seeds (P = 0.044). After adjustment for confounders, the risk of GD was 25% higher in the second tertile (OR: 1.25; 95% CI: 0.9, 2.3) and 51% higher in the third tertile (OR: 1.51; 95% CI: 0.54, 1.36) of PRAL compared to the first tertile (P trend = 0.023). A similar trend was seen for NEAP, with a 19% increased risk in the second tertile (OR: 1.19; 95% CI: 0.78, 1.84) and 48% in the third tertile (OR: 1.48; 95% CI: 0.9, 2.3) relative to the first tertile.

Higher dietary acid load is associated with an increased risk of GD. Further studies are needed to confirm these findings and elucidate underlying mechanisms.

Considering the high prevalence of irritable bowel syndrome (IBS), high medical costs, and the lack of complete treatment, paying attention to the psychological processes of these patients can lead to providing cognitive solutions to eliminate or reduce pain, and improve its consequences and psychological effects. Accordingly, the current study aims to evaluate the relationship between mindfulness and quality of life, IBS symptom severity, severity of extra-intestinal symptoms, and obesity among a cross-sectional sample of patients with IBS.

In this analytical cross-sectional study, 110 adults with IBS were confirmed according to Rome IV criteria by a physician. They were selected using cluster sampling. Various questionnaires and tools, including sociodemographic, physical activity, 24-item Five Facet Mindfulness Questionnaire Short Form (FFMQ-24), IBS-Quality of Life Instrument (IBS-QOL), IBS Symptom Severity Scale (IBS-SSS), and IBS Extra-intestinal Symptom Severity Scale (IBS-EISSS) were applied. SPSS software version 23 (IBM SPSS Statistics, Armonk, USA) was used for data analysis.

Inverse significant association was observed between the mindfulness score and BMI, Global IBS-SSS score, and Global IBS-EISSS score (p < 0.05). Moreover, the mindfulness score was inversely associated with weight in adjusted models (model 2: B = -0.16, p = 0.02; model 3: B = -0.21, p = 0.002). Mindfulness was associated with fewer odds of being overweight and obese in patients with IBS (OR = 0.93, CI: 0.87-0.98).

Mindfulness had a significant relationship with obesity, the IBS symptom severity, as well as severity of extra-intestinal symptoms among those who suffer from IBS.

Previous studies examining the relationship between plant-based diets and breast cancer (BrC) have provided conflicting evidence. To address these inconsistencies, we aimed to evaluate the association between the plant-based diet index (PDI), healthful PDI (hPDI), and unhealthy PDI (uPDI) with the odds of BrC in Iranian women.

The current case-control research was performed on 133 Iranian women with BrC and 265 controls. The study subjects were selected from hospitals in Tehran. PDI, hPDI, and uPDI were categorized into eighteen food groups based on nutrient composition similarity. The relationship between PDIs and BrC was assessed using logistic regression.

After adjusting for confounding factors, the chance of developing BrC was lower in the highest tertile of hPDI compared to the lowest tertile (odds ratio (OR) = 0.495; 95% confidence interval (CI): 0.274-0.891; P = 0.019). In addition, postmenopausal women in the second and last tertiles of hPDI had lower odds of BrC than those in the first tertile (T) (T2: OR = 0.342; 95% CI: 0.141-0.828; P = 0.017- T3: OR = 0.262; 95% CI: 0.107-0.639; P = 0.003) in the adjusted model. Furthermore, in premenopausal women in the highest tertile of uPDI, the odds of BrC were increased compared to the lowest tertile (OR = 2.546; 95% CI: 1.051-6.167; P = 0.038) in the adjusted model.

Adherence to a healthy plant-based dietary pattern, including vegetables, fruits, whole grains, nuts, and legumes, seems to be beneficial for BrC prevention, particularly in postmenopausal women. Future prospective cohort studies that consider menopausal status and the type of BrC are needed to support these findings.

This study aims to investigate the association between the MIND index (Mediterranean- Dietary approaches to Stop Hypertension diet Intervention for Neurodegenerative Delay) and attention-deficit hyperactivity disorder (ADHD) in the Iranian children. It builds upon existing research that highlights the role of dietary antioxidants in alleviating psychological disorders, cognitive impairments, and memory deficits. Additionally, previous studies have separately explored the beneficial effects of the Mediterranean and DASH diets on these issues. A case-control study was undertaken in Iran, involving a sample of 360 children and adolescents aged 7-13 years. Participants were divided into two groups, namely the case group (n = 120) and the control group (n = 240), with age and sex being matched between the groups. The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV-TR) was employed for the diagnosis of ADHD. The MIND diet score was computed using the food intake data acquired from the Food Frequency Questionnaire (FFQ) completed by the subjects. The mean ± SD for the age and BMI of the study population was 8.76 ± 1.64 years and 16.90 ± 3.58 kg/m2, respectively. The mean score of MIND in this study was 27.93. After adjustment for potential confounder in the final model, subjects in highest compared to the lowest quartile of MIND diet score had significantly lower odds of ADHD (OR = 0.59, 95% CI 0.37-0.83; P-trend = 0.019). This study provides valuable evidence suggesting that adherence to the MIND diet is associated with decreased odds of ADHD.

The study aimed to determine whether participation in professional sports, exercise in a sports/health center, or independent exercise (dependent variables) is associated with 11 health behavior-related indicators (independent variables) compared to having no exercise.

The survey involved 293 professional Lithuanian athletes, 2,120 who exercise independently or in a sports/health centre and perform at least one of the 20 most popular exercise types in Lithuania (hereafter referred to as "E-20"), and 3,400 who do not exercise. The participants were aged 18-74 years.

The study uniquely examines a comprehensive range of 11 health-related indicators: body mass index, subjective health, depressed mood, stress, sedentary behavior, physical activity, sleep, alcohol consumption, smoking, overeating, and breakfast consumption. We examined whether these indicators differ between the three populations studied, whether they are associated with specific types of the E-20 exercises, and whether these patterns differ between men and women.

Our study indicates that participants who engaged in physical activity generally scored higher on various health-related scales compared to those who were inactive. These benefits include reductions in depressed mood, stress, body mass index, and binge eating, as well as improvements in the regularity of breakfast consumption, vigorous physical activity, moderate to vigorous physical activity, and sleep duration (notably in men).

There is growing interest in the connection between ultra-processed food (UPF) and cardiovascular diseases. This study explores how UPF intake relates to the severity of coronary artery disease (CAD) in at-risk patients undergoing elective angiography.

Data covering demographic, and clinical details, and dietary intakes (using a validated food frequency questionnaire) were gathered from the Nutrition Heshmat Registry (NUTHER) in Rasht, Iran. UPF consumption was evaluated using the NOVA food classification system, with the exception of core grain foods. The study comprised 1,015 participants, who were classified based on the severity of CAD using the Gensini score (severe-CAD = Gensini score ≥ 60). Logistic regression was used to analyze the odd ratio (OR) and 95%confidence interval (95%CI) for severe-CAD across UPF quartiles (percentage of energy), and for each 10% increase in UPF intake. Restricted cubic spline (RCS) regression was employed to explore nonlinear relationships between UPF and severe-CAD.

Following controlling for potential confounders, normal-weight participants in the highest quartile of UPF exhibited about 5 times greater odds of severe-CAD than those in the lowest category (OR(95%CI): 5.01 (1.89, 13.29); P-for-trend = 0.002). Overweight/obese participants in the higher UPF quartiles had approximately 2-3.5 times greater odds for severe-CAD than those in the 1st quartile (ORs (95%CIs): 3rd quartile 1.91 (1.14, 3.21); and 4th quartile: 3.53 (2.07, 5.99); P-for-trend < 0.001). Each 10% increase in daily energy intake from UPF was associated with about 1.6-2 times increased severe-CAD risk among overweight/obese and normal-weight individuals (ORs (95%CIs) of 1.64 (1.28, 2.11), and 2.24 (1.24, 4.05), respectively). RCS analysis showed an upward trend toward higher UPF intake in relation to increased risk of severe-CAD (P-for-overall-trend < 0.0001; P-for-nonlinearity = 0.005).

The findings obtained underscore a direct association between UPF and the risk of CAD progression among at-risk patients, independent of BMI. However, further prospective studies are essential to confirm these results and better understand this relationship.

The study examines how ice and snow sports participation, fitness, perceived social support, and access to winter sports facilities affect health outcomes in China. Understanding winter sports' health benefits is essential for improving public health in colder parts of China, where their popularity is rising.

A sample of 875 Chinese from various regions was used to examine variable relationships using structural equation modeling (SEM) and route analysis.

Health outcomes, fitness, winter sports facilities, and ice and snow sports participation were positively associated. A significant correlation (β = 0.22, p < 0.001) was established between ice and snow sports participation and physical fitness, highlighting the impact of winter sports on health. Perceived social support for winter sports improves cold weather tolerance (β = 0.27, p < 0.001), emphasizing the role of social networks in resilience. The correlation between physical fitness and access to winter sports facilities (β = 0.31, p < 0.001) highlights the importance of physical talents in winter sports participation. Positive associations between physical fitness (β = 0.25, p < 0.001) and winter sports social support (β = 0.19, p < 0.001) suggest favorable health and well-being impacts. Physical fitness moderates the health benefits of ice and snow sports participation (β = 0.12, p < 0.05), whereas perceived social support for winter sports mediates the effect (β = 0.09, p < 0.05).

The findings emphasize the importance of supporting ice and snow activities and providing infrastructure to promote health. Physical fitness and improved health outcomes on social support can improve winter sports benefits. Public health initiatives may leverage this information to encourage active living and enhance health.

Maternal position plays an essential role in achieving labour progress as it supports the physiological mechanisms of labour. Evidence supports that adopting upright positions may facilitate physiological childbirth.

To describe the use of various positionsamong nulliparous pregnant women in the last 24 h before birth and describe physical positions in relation to maternal and neonatal outcomes at time of birth.

Cohort study of 105 nulliparous women with an uncomplicated singleton pregnancy. Body position was measured by two triaxial accelerometers (SENS motion®), and maternal and neonatal outcomes at time of birth were obtained from medical records. Positions were described for the total population and further stratified into two groups based on time spent in sacrum non-flexible (lying, sitting) and sacrum flexible (standing, walking) positions.Descriptive analyses of maternal position in relation to birth outcomes and comparisons between the two groups were made.

Lying down was the mostfrequent position adapted, with a median time of 659 (78;1208) minutes, equivalent to 11.0 hours. Women spent 1152 (687;1369) minutes in sacrum non-flexible positions, equivalent to 19.2 hours or 80 % of the last 24 hours before childbirth. More than 90 % gave birth in a sacrum non-flexible position. Women spending more time in sacrum non-flexible positions had more epidural analgesia than women spending more time in sacrum flexible positions (42.6 % and 21.3 %, p = 0.03).

Women spent 80% of their time in sacrum non-flexible positions during the last 24 hours before childbirth. At birth, more than 90% gave birth in sacrum non-flexible positions.

The Portfolio Diet (PD) is a plant-based dietary approach that has been associated with a reduced risk of cancer-related mortality. The aim of this study was to investigate the relationship between PD score (PDS) and breast cancer (BC) risk in Iranian women, providing insights into the impact of diet on BC risk across different menopausal stages.

The current case-control study included 133 women with newly diagnosed BC and 265 controls without any neoplastic disorders, all of whom were referred to the oncology department of two referral hospitals in Tehran, Iran. A validated semi-quantitative food frequency questionnaire, consisting of 168 food items, was used to gather dietary information. Additionally, odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to assess the associations of BC with the PDS and its components, using univariate and multivariate logistic regression analysis.

After adjusting for variables in multivariate analysis, a significantly lower association was observed between each unit increase in plant protein intake and the odds of BC in the total population (OR = 0.399, 95% CI: 0.170-0.936). Based on menopausal status, a significant association was found between PDS and the odds of BC in premenopausal women (OR = 0.914, 95% CI: 0.845-0.989). Additionally, in the postmenopausal women, significantly lower odds of BC were observed with each unit increase in plant protein intake in the adjusted model (OR = 0.078, 95% CI: 0.015-0.399).

This study provides novel insights into the protective role of PD against BC, demonstrating that a higher PDS is associated with a significant reduction in BC odds among premenopausal women. Plant protein intake also demonstrated a protective effect against BC in both the overall population and postmenopausal women. These findings highlight the potential benefit of the PD as a preventative dietary strategy against BC, particularly emphasizing the role of plant protein.

Cardiovascular diseases are a leading cause of global mortality, with diet playing a key role in their progression. The Atherogenic Index of Plasma (AIP) is a predictive marker for cardiovascular risk, but its association with dietary intake across cardiometabolic phenotypes remains underexplored. This study investigates the relationship between dietary intake and AIP, hypothesizing that energy intake and macronutrients influence AIP and, consequently, cardiovascular risk.

This cross-sectional study analyzed data from 9,515 participants aged 35-55 in the Azar cohort study. Based on Body Mass Index (BMI) and metabolic syndrome (MetS), participants were classified into four phenotypes: metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUHNW), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUHO). Dietary intake was evaluated using a semi-quantitative food frequency questionnaire (FFQ), and AIP was calculated. Adjustments were made for age, gender, socioeconomic status, and physical activity.

A notable difference was observed in demographic and clinical status between cardiometabolic groups of males and females. The AIP was highest in the MUHNW (0.42 for males; 0.28 for females) and lowest in the MHNW (0.05 for males; -0.05 for females, P < 0.001). There was a statistically significant difference in the mean energy intake and the percentage of energy intake from protein among the cardiometabolic phenotypes (p < 0.001). After adjusting for confounders, only weak but meaningful correlations remained for energy, carbohydrate, and protein intake in the MUHO (r = 0.048, P = 0.01; r = 0.057, P = 0.003; and r = 0.050, P = 0.01) and for carbohydrate and lipid intake in the MHO (r = 0.034, P < 0.01 and r = -0.055, P < 0.001).

The study found weak but meaningful correlations between energy, carbohydrate, and protein intake and AIP in the MUHO phenotype and between carbohydrate and lipid intake and AIP in the MHO phenotype. This highlights the role of energy and carbohydrates in AIP within specific subgroups. Future research should focus on the effects of macronutrient combinations on AIP and long-term dietary impacts on metabolic health instead of BMI.

The associations between serum hemoglobin (Hb) levels and bone mineral density (BMD) were investigated in population of the 4th Iranian Multicenter Osteoporosis Study (IMOS). A positive relationship between Hb levels and BMD at hip and femoral neck were detected only in men.

Previous studies have investigated the relationship between hemoglobin (Hb) levels and bone mineral density (BMD) with controversial findings. This study aimed to evaluate this association using data from the 4th Iranian Multicenter Osteoporosis Study (IMOS), a population-based national survey, including a population sample aged 50 years and older.

The present study was conducted as a cross-sectional data analysis derived from the fourth round of the IMOS. Demographic information, Hb levels, and BMD measurements were collected. BMD was measured with dual-energy X-ray absorptiometry (DXA). Low BMD (osteopenia/osteoporosis) and osteoporosis were defined as a T-score less than -1 and less than -2.5 at each site including hip, femoral neck, or lumbar spine, respectively. Multiple linear regression analysis was used to assess the relationship between Hb levels and BMD.

This study included 1,426 participants (54.2% female) with the mean age of 62.6 ± 8.0 years. The mean Hb levels among patients with or without osteoporosis were 12.9 ± 2.0 mg/dl and 13.1 ± 1.9 mg/dl, respectively (p-value = 0.08). It was demonstrated a positive relationship between Hb levels and BMD at hip (β = 0.0079, 95% CI: 0.002- 0.0135, p-value = 0.006) and femoral neck (β = 0.0064, 95% CI: 0.0015- 0.0113, p-value = 0.01) in only men. However, there was no significant correlation between Hb levels with low BMD and osteoporosis in either gender.

Our findings showed a favorable relationship between Hb levels and BMD at the hip and femoral neck, particularly in men. This highlights gender and site-specific distinctions between hematological and skeletal health..Future studies should unravel these possible associations and investigate the underlying mechanisms.

Recent studies suggest a link between dietary fat quality and obesity. Genetic risk scores (GRS) can predict obesity risk based on genetic factors. This study investigates how GRS and fatty acid quality affect visceral adiposity index (VAI) and body adiposity index (BAI) in overweight and obese women.

In this study, 278 overweight and obese women (aged 18-58) participated. We have used a comprehensive food frequency questionnaire (FFQ) to evaluate dietary intake and the fatty acids quality indexes. We have employed standard methods to measure biochemical factors, anthropometrics, and physical activity levels. Finally, the GRS was created by combining three SNPs [CAV-1 (rs3807992), Cry-1 (rs2287161), and MC4R (rs17782313)].

The study found that there was no significant association between the quality of fat intake (as measured by CSI score and N6/N3 score) and VAI or BAI in both crude (B = 70.70, SE = 35.14, CI:1.81-139.55, P = 0.04) and adjusted models (B = 93.67, SE = 39.28, CI:16.68-17.68, P = 0.01). CSI provides information on cholesterol and saturated fats. However, there was a notable interaction between the GRS and the N6/N3 score on VAI, suggesting that obese women with high obesity-related SNPs who consumed foods with a higher ratio of N6/N3 fatty acids tended to have an increased VAI.

This study shows; that eating more food sources containing a higher ratio of N6/N3 may be the reason for the increase in VAI in obese women who have high obesity-related SNPs and emphasizes the matter of personalized nutrition in obesity issues.

The happiness and well-being of individuals are among the most important components of life. However, there remains a lack of evidence regarding the relationships between students' happiness, vigor, and self-esteem on the one hand and various complex factors on the other hand.

We conducted a cross-sectional study involving 397 students from various Lithuanian universities. We determined students' happiness, self-esteem, vigor, healthy lifestyles, perceived stress, personality traits, academic achievements and motivation by using validated scales.

The study indicates that while happiness and self-esteem are not linked to healthy lifestyles, vigor is positively associated with moderate-to-vigorous physical activity (MVPA) and healthy eating, and negatively with body mass index (BMI). Happiness and vigor inversely relate to stress, and happiness and self-esteem inversely relate to depression. Vigor is positively related to extraversion, and self-esteem to neuroticism. Happiness, vigor, and self-esteem are not linked to academic achievements, but happiness relates to non-utilitarian decisions, and self-esteem to emotional intelligence and non-utilitarian decisions. Happiness, vigor, self-esteem were not linked to intrinsic motivation to study, but self-esteem was inversely related to amotivation and childhood violence. This study fills the research gap and deepens the understanding of what determines students' happiness and vigor, and self-esteem.

The primary aim of our study is to explore how moderate-intensity physical activity (MPA), vigorous-intensity physical activity (VPA), moderate-to-vigorous physical activity (MVPA), and sedentary behavior (SB) in men and women (ages 18-74; 4545 females and 1824 males) are associated with age, education, psychological factors (cognitive reflection/"cold" mind, emotional intelligence (E), impulsivity, perceived stress), health behaviors (overeating, breakfast consumption, smoking, alcohol use), body mass index (BMI), and sleep duration.

The information was collected by means of an online survey ( https://docs.google.com/forms/ ) to ensure the anonymity of participation and confidentiality of data.

MVPA and SB in men and women are significantly influenced by education, age, BMI, lifestyle, and psychological factors, with some gender differences. Higher education reduces MVPA and increases SB, while age lowers SB and raises MVPA in women. BMI inversely affects MVPA and VPA, and breakfast supports higher activity levels, while overeating and alcohol (in men) are linked to lower MVPA and higher SB. Sleep duration weakly affects activity structure but inversely relates to SB. While Cognitive Reflection Test (CRT) scores-an indicator of logical reasoning-do not show a significant positive impact on physical activity levels (MPA, VPA, or MVPA) in either gender, they are associated with increased sedentary behavior in women. Emotional Intelligence (EI), however, plays a clear and positive role: higher EI is strongly associated with increased VPA and MVPA in both men and women, especially in women, and inversely related to SB in both genders.

The results of our study suggest that enhancing EI ("hot" mind) may be more effective than reasoning skills ("cold" mind) in promoting physical activity and reducing sedentary behavior, particularly in women. These findings highlight EI's potential as a key driver of active lifestyles, while logical reasoning appears to have a lesser impact.

This study protocol specifies the primary research line and theoretical framework of the 2023 Survey of the Psychology and Behavior of the Chinese Population. It aims to establish a consistent database of Chinese residents' psychological and behavioral surveys through multi-center and large-sample cross-sectional surveys to provide robust data support for developing research in related fields. It will track the public's physical and psychological health more comprehensively and systematically.

The study was conducted from June 20, 2023 to August 31, 2023, using stratified and quota sampling methods. A total of 150 cities across 800 communities/villages were surveyed, selected from China (Despite extensive coordination, we have been unable to contact our counterparts in the Taiwan region of China to obtain relevant statistical data). The questionnaires were distributed to the public one-on-one and face-to-face by trained surveyors. The questionnaires included basic information about the individual, personal health status, basic information about the family, the social environment in which the individual lives, psychological condition scales, behavioral level scales, other scales, and attitudes towards topical social issues. Supervisors conducted quality control during the distribution process and returned questionnaires, logically checked and cleaned for data analysis.

Data collection has been finished, and scientific outputs based on this data will support the development of health promotion strategies in China and globally. In the aftermath of the pandemic, it will guide policymakers and healthcare organizations to improve their existing policies and services to maximize the physical and mental health of the Chinese population.

This study was filed in the National Health Security Information Platform (Record No.: MR-37-23-017876) and officially registered in the China Clinical Trials Registry (Registration No.: ChiCTR2300072573).

Polycystic ovary syndrome (PCOS) is a common, heterogeneous clinical syndrome affecting women. Investigating oxidative stress in women is crucial, as it is linked to insulin resistance and endothelial dysfunction. Chlorogenic acid, a bioactive component found in green coffee, has numerous documented health benefits. This study aimed to assess the beneficial effects of green coffee consumption on paraoxonase-1 (PON-1) activity and malondialdehyde (MDA) levels in women with PCOS.

This study was a double-blind randomized clinical trial that included 44 patients with PCOS. Participants were randomly assigned to either the intervention or control group. For 6 weeks, the intervention group (n=22) received 400 mg of green coffee supplements, while the control group (n=22) received 400 mg of a starch-based placebo. Anthropometric indices, dietary assessments, and physical activity levels were evaluated before and after the 6-week intervention period. Additionally, blood samples were collected for laboratory analysis.

Supplementation with green coffee increased PON-1 levels by 3.5 units, a significant finding (p=0.038). Additionally, the intake of green coffee supplements significantly reduced blood cholesterol levels by 18.8 units (p=0.013) and triglyceride levels by 6.1 units (p=0.053). However, no significant differences were observed in the levels of MDA, high-density lipoprotein, low-density lipoprotein, fasting blood sugar, insulin, or homeostatic model assessment of insulin resistance as a result of the intervention.

Supplementation with green coffee alters PON-1 activity and cholesterol levels in women with PCOS. However, it has no significant impact on MDA levels or glycemic status.

It has been documented that regular physical activity is considered one of the most effective strategies for preventing diabetes; however, it is not the sole contributing factor. Therefore, we decided to evaluate the meditation effect of liver function and anthropometric indices on the relationship between incidence of diabetes and physical activity (PA) in the Azar cohort population.

Subjects who were diabetic in the baseline phase from 15,006 participants in study of azar cohort population were excluded and to follow up, a total of 13,253 people was included in the analysis. Demographic characteristics, physical activity, 10 anthropometric indices (AI) and seven liver indices (LI) were measured. Evaluated and displayed using Pearson correlation heatmap and canonical correlation of liver and anthropometric indices. The Generalized Structural Equation Modeling (GSEM) with the Maximum Likelihood method employed to estimate the model.

During the follow-up years, a total of 685 participants developed diabetes. The measurements of the AI were significantly higher in subjects with diabetes (P < .001). Patients with diabetes were older, had a higher proportion of women, and had lower values of PA (P < .05). Body Roundness Index (BRI) and Waist height ratio (WHtR) exhibited the largest AUCs for predicting diabetes onset risk (both AUC = 0.6989) among these anthropometric measures. The increase in AI (RR [95%CI] = 1.25 [1.22,1.29], P < .001) and liver enzyme (LE) (RR [95%CI] = 1.14 [1.08.1.19], P < .001) increase the risk of diabetes by 25% and 14%, respectively. Despite the mediation effects of AI and Liver Enzymes for an increase of one MET of PA, the risk of developing diabetes decreases by 5% (RR [95% CI] = .95 [.92,.99], P = .013). Around VAF = 53% of the association between PA and diabetes onset (Total effect: RR [95% CI] = .90 [.87,.94], P < .001) was mediated by AI and LE.

A low level of PA was found to be significantly correlated with high levels of AI and LI, all of which are associated with an increased risk of developing diabetes. These analyses provide evidence that when the relationship between PA and diabetes is mediated by AI and LI this association becomes stronger, with AI playing a more significant role than LI.

The current study aimed to evaluate the association between the intake of plant-based protein, animal-based protein, total protein, and the ratio of plant to animal protein with sleep quality and quality of life in patients undergoing hemodialysis.

In this cross-sectional study, 479 adult patients undergoing dialysis for a minimum of 3 months were included. The dietary intake was calculated using information from a validated 168-item semi-quantitative food frequency questionnaire. Quality of life (QOL) was assessed using the Kidney Disease Quality of Life Short Form (KDQOL-SF 1.3). and the Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality.

In this study, the mean age of the participants was 58.18 years (± 14.25 years), with the majority being male (58.2%). After adjusting for potential confounders, significant positive associations were observed between total protein intake (β = 0.12, p = 0.03) and quality of life (QOL). Conversely, there were significant negative associations between the ratio of plant to animal protein intake (β = -0.94, p < 0.01) and QOL. Furthermore, significant negative associations were found between total protein intake (β = -0.02, p < 0.05) and animal protein intake (β = -0.19, p < 0.05) with poor sleep quality. Additionally, there were significant positive associations between the ratio of plant to animal protein intake (β = 0.188, p < 0.05) and poor sleep quality.

Increased consumption of animal protein is associated with improved sleep quality and Quality of Life (QOL) in patients undergoing hemodialysis (HD). Further research, especially prospective studies, is required to confirm these associations.

It has been shown that chronic inflammation is a significant factor in cancer development and progression. The current study aimed to investigate whether a higher score on the empirical dietary inflammatory pattern (EDIP), which indicates a more pro-inflammatory diet, is related to higher odds of breast cancer in Iranian women.

In the present case-control study, subjects in the case (n = 133) and control (n = 265) groups were chosen from the hospitals in Tehran, Iran. The cases consisted of women with newly diagnosed breast cancer, while the controls were selected from other parts of the same hospital and had no history of cancer or hormone therapy. Individuals whose reported energy intake deviated by three standard deviations above or below the mean energy intake of the population were excluded from the study. A reliable and valid semi-quantitative food frequency questionnaire was used to determine the participants' dietary intake. Additionally, the association between breast cancer and EDIP was evaluated by logistic regression analysis in both crude and adjusted models.

The median scores of EDIP in the case and control groups were 0.65 and 0.61, respectively. The findings also indicated that, in the adjusted model, the odds of developing breast cancer significantly increased in the last tertile of EDIP compared to the first tertile (odds ratio (OR) = 1.859; 95% confidence interval (CI): 1.059-3.265; P = 0.031). Additionally, after adjusting for potential confounders, higher odds of breast cancer were observed in the last tertile of EDIP compared to the first tertile in postmenopausal women (OR = 2.516; 95% CI: 1.081-5.856; P = 0.033).

The current study indicated that individuals with a higher pro-inflammatory diet score were more likely to develop breast cancer.

Results from studies investigating the association between ultra-processed foods (UPFs) and breast cancer are scarce and, in some cases, contradictory. Therefore, we aimed to evaluate the association between the intake of processed foods (PFs) and UPFs with the risk of breast cancer in Iranian women.

The present case (n = 133) - control (n = 266) study was carried out at two general hospitals in Tehran, Iran. A 168-item semi-quantitative food frequency questionnaire was used to assess the participants' dietary intake. Also, the NOVA classification was used to identify PFs and UPFs. The association between PFs and UPFs with the odds of breast cancer was analyzed using logistic regression models.

According to Model 1 of conditional logistic regression, the odds of breast cancer were higher in the last tertile of UPFs than in the first tertile (odds ratio (OR) = 1.930; 95% confidence interval (CI): 1.080-3.449). In Model 2, no significant association was observed between the second and last tertiles of PFs and UPFs with the odds of breast cancer compared to the reference tertile. Also based on menopause status, the odds of breast cancer increased in the last tertile only among premenopausal women in Model 2 (OR = 3.656; 95% CI: 1.326-10.079).

This study demonstrated that higher consumption of UPFs is associated with higher odds of breast cancer in premenopausal women.

Dietary patterns play a crucial role in the development and management of metabolic syndrome (MetS). The Healthy Beverage Index (HBI) is a novel tool that assesses the quality of beverage choices in the diet and provides insights into their potential impact on metabolic health. The aim of this study was to investigate the association between the HBI and the MetS.

This cross-sectional study was conducted using data collected at baseline from the Ravansar Noncommunicable Disease Cohort Study. A total of 9,025 participants aged 35 to 65 years were included in the analysis. HBI was calculated using food items from the Food Frequency Questionnaire (FFQ). MetS status was defined according to established criteria, and logistic regression analysis was performed to assess the association between HBI scores and MetS, adjusting for potential confounding variables.

In our study, 41.13% of the population was found to have MetS, with a significant association between MetS and tertiles of HBI. Furthermore, the logistic regression model showed a significant inverse association between HBI scores and the odds of developing a MetS (OR = 0.90; 95% CI: 0.86, 0.94), even after adjusting for confounding factors, emphasizing the potential protective effect of higher HBI scores.

Increased HBI scores were associated with lower risk of MetS, emphasizing the importance of choosing health-promoting beverages in controlling MetS. These findings support the association between dietary habits and metabolic health and provide practical guidance for individuals and public health initiatives aimed at improving metabolic outcomes.

According to epidemiological studies, unhealthy dietary patterns and lifestyle lead to rising obesity and cardiometabolic diseases in Iran. Hybrid techniques were used to identify a dietary pattern characterized by fiber, folic acid, and carotenoid intake due to their association with cardiometabolic risk factors such as anthropometric measurements, blood pressure, lipid profile, C-Reactive Protein (CRP), Plasminogen Activator Inhibitor (PAI), Homeostatic Model Assessment Index (HOMA Index), cardiometabolic index (CMI), and monocyte chemoattractant protein (MCP-1). So, the objective of the recent study is to compare the reduced-rank regression (RRR) and partial least-squares (PLS) approaches to principal component analysis (PCA) for estimating diet-cardiometabolic risk factor correlations in Iranian obese women.

Data on dietary intake was gathered from 376 healthy overweight and obese females aged 18 to 65 years using a 147-item food frequency questionnaire (FFQ). In this cross-sectional study, participants were referred to health centers of Tehran. Dietary patterns were developed using PCA, PLS, and RRR, and their outputs were assessed to identify reasonable patterns connected to cardiometabolic risk factors. The response variables for PLS and RRR were fiber, folic acid, and carotenoid intake.

In this study, 3 dietary patterns were identified by the PCA method, 2 dietary patterns by the PLS method, and one dietary pattern by the RRR method. High adherence to the plant-based dietary pattern identified by all methods were associated with higher fat free mass index (FFMI) (P < 0.05). Women in the highest tertile of the plant-based dietary pattern identified by PLS had 0.06 mmol/L (95% CI: 0.007,0.66, P = 0.02), 0.36 mmHg (95% CI: 0.14,0.88, P = 0.02), and 0.46 mg/l (95% CI: 0.25,0.82, P < 0.001), lower FBS, DBP, and CRP respectively than women in the first tertile. Also, PLS and RRR-derived patterns explained greater variance in the outcome (PCA: 1.05%; PLS: 11.62%; RRR: 25.28%), while the PCA dietary patterns explained greater variance in the food groups (PCA: 22.81%; PLS: 14.54%; RRR: 1.59%).

PLS was found to be more appropriate in determining dietary patterns associated with cardiometabolic-related risk factors. Nevertheless, the advantage of PLS over PCA and RRR must be confirmed in future longitudinal studies with extended follow-up in different settings, population groups, and response variables.

Phytochemicals are compounds found in fruits, vegetables, whole grains, nuts and legumes that are non-nutritive but have bioactive properties. A high intake of these compounds is essential for optimal health and disease prevention. No study has investigated the association between Dietary Phytochemical Index (DPI) and polyneuropathy in patients with diabetes. This study aimed to examine the association between DPI and Diabetic Sensory-motor Polyneuropathy (DSPN) in a case-control study. In this case-control study, a total of 185 diabetic patients with DSPN (case group) and 185 sex- and age-matched diabetic patients without neuropathy (control group) were enrolled in this study. Participants were 30-60 years old. A validated food frequency questionnaire was used to measure the dietary intake of all participants. Daily energy derived from phytochemical-rich foods was used to calculate the DPI score. Toronto clinical neuropathy score was applied to define DSPN. Anthropometric data and fasting blood glucose levels were measured using standard methods. The Binary logistic regression was used to estimate Crude and multivariable-adjusted OR (95% CI) for DSPN across tertiles of DPI for the whole population. In the crude model, there was a significant trend across the tertile of DPI (OR highest vs. lowest tertile of DPI = 0.33; 95%CI 0.18, 0.52; P-trend < 0.001). After controlling for age, sex, and energy, a significant reverse association was observed between DPI and DSPN (OR highest vs. lowest tertile of DPI = 0.27; 95%CI 0.15, 0·48; P-trend < 0.001). Moreover, after adjusting for a wide range of confounding variables such as energy intake, physical activity, education, smoking status, and HbA1c, participants in the third tertile of DPI had 75% reduced odds for DSPN (95%CI 0.14, 0.45; P-trend < 0.001). Finally in the full adjusted model, after further adjustment for BMI, observed significant association was remained (OR highest vs. lowest tertile of DPI: 0.24; 95% CI 0.13, 0.14; P-trend < 0.001). Higher intakes of phytochemical-rich foods are associated with lower odds of DSPN.

Osteoporosis is a growing public health concern, particularly among the aging population. This study aimed to evaluate the association between osteoporosis and quality of life (QoL) in a sample of older adults.

This cross-sectional study utilized data from all the participants of Bushehr Elderly Health program (BEHP), phase 2. QoL was assessed using the 12-Item Short Form Survey (SF-12 Questionnaire), and participants were classified as having osteoporosis or not based on the WHO diagnostic criteria. The physical (PCS) and mental (MCS) component summaries of QoL were estimated. The association between osteoporosis and QoL was evaluated separately for men and women, considering various health and lifestyle factors using linear regression analysis.

The study included 2,399 participants (average age 71.27 ± 7.36 years). 1,246 were women and 1,153 were men. Osteoporosis was present in 59% of women and 23% of men. Participants with osteoporosis had significantly lower PCS scores compared to those without osteoporosis (women: 38.1 vs. 40.2, p < 0.001; men: 44.3 vs. 45.8, p: 0.002). However, there was no statistically significant difference in MCS scores. Stratified by sex, osteoporosis was significantly associated with PCS in women [β = -2.14 (-3.13, -1.15)] and men [β = -1.53 (-2.52, -0.54)]. After accounting for relevant variables, the association remained significant in women [β=-0.95 (-1.87, -0.03)], but not in men [β=-0.63 (-1.55,0.28)].

This study highlights the significant association between osteoporosis and the physical component of QoL in both older men and women, particularly among women. Further research and interventions focusing on enhancing physical QoL in individuals with osteoporosis are warranted to promote healthier aging.

Obesity has been linked to various conditions, including nephrolithiasis. Given the rising prevalence of both nephrolithiasis and obesity in older adults, this study aimed to examine the association of different obesity-related indices with nephrolithiasis.

This cross-sectional study included 2419 individuals (mean age 69.34 ± 6.40; 51.92 % female) from the Bushehr Elderly Health (BEH) program, a population-based measured using Dual-energy X-ray absorptiometry (DXA), while nephrolithiasis history was assessed through medical records. The associations between obesity-related indices and nephrolithiasis were analyzed using multivariable logistic regression models, adjusted for relevant confounders.

Among the 2419 participants, 212 (8.76 %) had a history of nephrolithiasis. In the overall population, only the android-to-gynoid fat mass (FM) ratio was significantly associated with nephrolithiasis (odds ratio [OR] 3.28, 95 % Confidence Interval [CI] 1.06-10.18). In females, the trunk-to-limb FM ratio (OR 2.62, 95 % CI 1.10-6.23) and the visceral adipose index (VAI) (OR 1.092, 95 % CI 1.005-1.187) were associated with nephrolithiasis. In males, only the body adipose index (BAI) was significantly associated with nephrolithiasis (OR 1.082, 95 % CI 1.017-1.151).

In this study, the android-to-gynoid FM ratio in the total population, the trunk-to-limb FM ratio and VAI in females, and BAI in males were significantly associated with nephrolithiasis. Monitoring and managing these indices may enhance quality of life for elderly individuals by facilitating early diagnosis of nephrolithiasis and preventing stone formation.